纳米药物的生物学特点及其机制研究概况  

An overview of researches on biological characteristics and mechanism of nanomedicine

作　　者：袁媛[1] 孙亚楠[1] 鲁传华[1,2] 

机构地区：[1]安徽中医药大学药学院 [2]安徽省中药研究与开发重点实验室,安徽合肥230031

出　　处：《中国药理学通报》2013年第8期1180-1184,共5页Chinese Pharmacological Bulletin

基　　金：2011年安徽省教育厅重点项目(No KJ2011A192)

摘　　要：纳米药物的小尺寸、高比表面和高活性赋予纳米给药系统较高的穿透生物膜屏障、组织器官选择性分布和缓控释等许多新的生物活性。该文根据现有的文献报道和本课题组的多年研究结果,对纳米药物吸收、转运和分布等体内过程和机制进行综合性阐述,旨在提高相关研究人员的关注和研究参考。The selective distribution, targeting, controlled release characteristics of nano-preparation are widely used in various fields, which results from quantum size effect, small size effect, surface effect and macroscopic quantum tunneling effect of nano- medicine. Mostly nanomedicine is absorbed in the form of nanomolecular aggregation that is different from traditional medicine. We summarize the absorption characteristics and mechanism, and make a comprehensive elaboration on the biological characteristics （small size, huge surface area）, the absorption in the body （permeabilized cells absorbtion, cell bypass, lymphatic absorption）, the transport and distribution（ selective targeting distribution） mechanisms of the nanomedicine and have an outlook on nano-preparation technologiy.

关 键 词：纳米药物 生物学特性 体内机制 选择性分布 靶向性 缓控释 

分 类 号：R05[医药卫生] R915