36例骨髓增生异常综合征患者铁过载状况调查  

Survey of the iron overload status in 36 patients with myelodysplastic syndrome

作　　者：韦树懿[1] 赖永榕[1] 

机构地区：[1]广西医科大学第一附属医院血液内科,南宁530021

出　　处：《临床血液学杂志》2013年第4期455-457,461,共4页Journal of Clinical Hematology

摘　　要：目的:调查36例骨髓增生异常综合征(MDS)患者的铁过载发生率及铁过载严重程度。方法:收集MDS患者36例,采用电化学发光法测定其血清铁蛋白(SF)。结果:36例MDS患者的SF为851.42(360.75～7 885.62)ng/ml,其中16例(44.4%)SF>1 000ng/ml。14例有输血史,SF为887.14(360.75～7 885.62)ng/ml,其中7例(50.0%)SF>1 000ng/ml;22例无输血史,SF为851.42(459.87～5 277.71)ng/ml,其中9例(40.9%)SF>1 000ng/ml。SF<1 000ng/ml者(20例)与SF>1 000ng/ml者(16例)的输血量分别为4U和36U,差异有统计学意义(P=0.024)。SF水平与输血总量呈正相关(P=0.000)。不同年龄段间SF值差异有统计学意义(P=0.022)。结论:本组MDS患者中16例(44.4%)出现铁过载。铁过载的发生与输血有关,但无输血史的患者中也有9例(40.9%)出现铁过载。Objective：To investigate the incidence and severity of iron overload in 36 patients with myelodysplastic syndrome（MDS）. Method：The serum ferritin（SF） was measured by electrochemiluminescence immunoassay（ECLIA） in 36 patients with MDS. Result：In the 36 patients with MDS,the SF value was 851.42（form 360.75 to 7 885.62）ng/ml,16 patients（44.4%） with SF1 000 ng/ml.Fourteen patients had a history of blood transfusion,the SF value was 887.14（from 360.75 to 7 885.62）ng/ml,7 cases（50.0%） with SF1 000 ng/ml.Twenty-two patients without history of blood transfusion,the SF value was 851.42（from 459.87 to 5 277.71）ng/ml,9 cases（40.9%） with SF1 000 ng/ml.The amount of blood transfusion in patients with SF1 000 ng/ml and SF1 000 ng/ml were 4 U and 36 U（P=0.024）.SF was positively correlated with the total blood transfusion（P=0.000）.There were significant differences in the SF values among difference ages（P=0.022）. Conclusion：In this study,16 patients（44.4%） are iron overloaded.The occurrence of iron overload is correlated with transfusion,but 9 cases（40.9%） in the patients without history of blood transfusion also occurs iron overload.

关 键 词：骨髓增生异常综合征 铁过载 

分 类 号：R733.3[医药卫生—肿瘤]