急性白血病中DPC4基因的表达研究  

Study of DPC4 gene expression in acute leukemia

作　　者：沈玲华 司今[2] 沈权[2] 雷秋模 

机构地区：[1]南昌市第三医院血液科,南昌330009 [2]武警总医院

出　　处：《临床血液学杂志》2013年第4期480-481,共2页Journal of Clinical Hematology

摘　　要：目的:探讨胰腺癌缺失基因(DPC4)在急性白血病(AL)中的表达情况及其与临床的关系。方法:采用RT-PCR方法检测32例AL患者骨髓细胞及9例正常人骨髓细胞DPC4表达情况。结果:AL患者骨髓细胞DPC4基因表达阳性率为75.00%,正常人骨髓细胞DPC4基因表达阳性率为77.78%,二者比较差异无统计学意义。结论:DPC4基因的表达缺失未参与AL的发病。Objective：To explore the role of DPC4（deleted in pancreatic carcinoma,locus4） gene expression in acute leukemia and its relationship with clinic. Method：We used RT-PCR to detect DPC4 gene expression in bone marrow cells of 32 patients with acute leukemia and 9 health people. Result：There was no significant difference in positive rate of DPC4 gene expression between acute leukemia patients and health people（75.00% vs 77.78%）. Conclusion：DPC4 gene may not play a role in acute leukemia.

关 键 词：急性白血病 DPC4基因 RT-PCR 

分 类 号：R733.71[医药卫生—肿瘤]