大剂量甲泼尼龙治疗p53异常的慢性淋巴细胞白血病1例并文献复习  

A case of high-dose methylprednisolone regimen for chronic lymphocytic leukemia with p53abnormalities and literature review

作　　者：朱家斌[1] 周立涛[1] 王晓炜[1] 张丽娟[1] 刘定胜[1] 于亮[1] 

机构地区：[1]南京医科大学附属淮安第一医院血液科,江苏淮安223300

出　　处：《临床血液学杂志》2013年第4期496-498,共3页Journal of Clinical Hematology

基　　金：江苏省自然科学基金项目(No:BK2010287);国家自然科学基金项目(No:81170489)

摘　　要：慢性淋巴细胞白血病（CLL）是一种淋巴细胞克隆性增殖的肿瘤性疾病,其特点为成熟形态的淋巴细胞在体内积聚使血液和骨髓中淋巴细胞增多,淋巴结、肝、脾肿大,最后累及淋巴系统以外的其他组织器官。CLL的临床进程异质性较大,由于Bi-net或Rai分期系统不能预测疾病早期是否进展,预测CLL预后的新指标不断被发现,其中位于17p的p53基因异常与CLL的预后密切相关。近来我科收治1例p53基因异常的CLL患者,现报告如下。A case of chronic lymphocytic leukemia（CLL） with p53gene abnormalities was reported and related literature were reviewed.The results showed that p53gene mutation and deletion were positive,chromosomal karyotype was complex,and the high-dose methylprednisolone regimen achieved a good therapeutic effect.It suggests that the detection of p53gene abnormalities is important for prognosis and treatment of CLL patients.Highdose methylprednisolone regimen is promising for CLL patients with p53abnormalities.

关 键 词：慢性淋巴细胞白血病 P53 甲泼尼龙 

分 类 号：R733.72[医药卫生—肿瘤]