ABCB1基因C3435T多态性与癫痫耐药关系的Meta分析  

ATP-binding cassette subfamily B member 1 transporter gene C3435T polymorphisms and resistance to antiepileptic drugs in epilepsy： a Meta analysis

作　　者：史菁菁[1] 李晓蕾 于锋[2] 张永[4] 廖清船[4] 

机构地区：[1]南通体臣卫生学校药学医技系,南通226007 [2]中国药科大学临床药学教研室,南京210009 [3]上海交通大学医学院附属上海儿童医学中心,上海200127 [4]南京医科大学附属南京儿童医院,南京210008

出　　处：《中华神经医学杂志》2013年第7期685-690,共6页Chinese Journal of Neuromedicine

基　　金：江苏省南京市医学科技发展基金（YKK10052,YKK09077）;中央高校基本科研业务费专项基金（JKY2011089）

摘　　要：目的运用Meta分析的方法综合评价ATP结合盒B亚家族成员1转运蛋白基因似BCBl）C3435T多态性与癫痫耐药的相关性。方法制定原始文献的纳入和排除标准及检索策略，检索中外文数据库，收集有关ABCB C3435T多态性与抗癫痫药物（AEDs）治疗反应相关性的研究报告。采用等位基因型fC（UST）以及共显性模型（CCVSTT，CTUSTT）、显性模型（CC＋CTVSTT）和隐性模型（ccVSCT＋TT）等基因遗传模型进行对比与定量综合分析，同时按人种所属地域（亚裔人与白种人、进行亚组分析。结果共23篇文献纳入Meta分析，包括3704例癫痫耐药患者和4160例治疗有效患者，入选文献无发表偏倚。统计分析显示：C3435T位点多态性与癫痫耐药无统计学关联：等位基因C与T相比，随机效应模型：OR=1．05，95％CI：0．94～1．18，P=-0．390。各基因型对比以及进行亚组分析后也未发现统计学关联。结论ABCBJC3435T多态性与癫痫耐药无关联。Objective To assess the relation of ATP-blndmg cassette subtamlly 15 memlger 1 （ABCB1） transporter gene C3435T polyrnorphisms and resistance to antiepileptic drugs （AEDs） in epilepsy by conducting a Meta-analysis. Methods Electronic search strategy was carded out among the databases fi＇om home and abroad to collect qualified research papers according to the inclusion and exclusion criteria. Studies with a case-control design involving the association of ABCB1 C3435T polymorphisms and resistance to AEDs were collected and analyzed by alleles （C vs T） and genotypes with co-dominant （CC vs TT and CT vs TT）, dominant （CC＋CT vs TT）, and recessive （CC vs CT＋TT） models in overall and in ethnicity subgroups. Results A total of 23 association studies including 7864 patients （3704 drug-resistant patients and 4160 drug-responsive patients） were pooled in this Meta-analysis. The allelic association of ABCB1 C3435T with risk of resistance to AEDs was not significant under random-effects model （OR=1.05, 95% CI： 0.94-1.18, P=0.390） in overall analyses. Similar results were also obtained for all genetic models in the stratified analyses by ethnicity subgroups. There was no publication bias. Conclusion The polymophisms of ABCBI C3435T may not invoNe in risk of resistance to AEDs in epilepsy.

关 键 词：癫痫 基因多态性 ATP结合盒B亚家族成员1转运蛋白基因 耐药性 META分析 

分 类 号：R742.1[医药卫生—神经病学与精神病学]