广东省中山市炎症性肠病的发病率及临床特点  

Incidence and clinical features of inflammatory bowel diseases in Zhongshan City of Guangdong Province

作　　者：朱振华[1] 曾志荣[1] 彭侠彪[2] 彭林[3] 郝元涛[4] 黄秀娟[5] 陈旻湖[1] 胡品津[1] 

机构地区：[1]中山大学附属第一医院消化科,广州510080 [2]中山市人民医院消化科 [3]中山市中医院肛肠外科 [4]中山大学公共卫生学院 [5]香港中文大学威尔士亲王医院内科及药物治疗科

出　　处：《中华消化杂志》2013年第6期390-393,共4页Chinese Journal of Digestion

基　　金：卫生行业科研专项（201002020）;国家临床重点专科建设项目（303004269002）

摘　　要：目的 明确广东省中山市IBD的发病率及其临床特点.方法 2011年7月至2012年6月在广东省中山市开展以人群为基础的前瞻性IBD流行病学调查,纳入所有中山市户籍的新发IBD病例,统计其发病数、中国年龄标准化后发病率及临床特点.结果 新发IBD患者48例,其中UC 31例,CD 17例.IBD标准化后发病率为3.14/10万,其中UC标准化后发病率为2.05/10万,CD标准化后发病率为1.09/10万.根据蒙特利尔分型,31例UC患者中,直肠炎11例（35.5％）,左半结肠炎13例（41.9％）,广泛结肠炎7例（22.6％）.17例CD患者中,病变部位为回肠末端型4例（其中1例合并上消化道型）,结肠型1例,回结肠型12例（其中3例合并上消化道型）；疾病行为是非狭窄非穿透型11例,狭窄型4例,穿透型2例.结论 广东省中山市UC发病率为2.05/10万,CD发病率为1.09/10万.UC以左半结肠炎最常见,CD病变部位以回结肠型最常见.Objective To investigate the incidence and clinical features of inflammatory bowel diseases （IBD） in Zhongshan City of Guangdong Province.Methods From July 2011 to June 2012,a prospective,population-based IBD epidemiological survey was conducted in Zhongshan City of Guangdong Province.All newly diagnosed IBD cases with Zhongshan census register were enrolled.The number of cases,Chinese age-standardized incidence and clinical features were analyzed.Results There were 48 new cases of IBD,of which 31 cases were ulcerative colitis （UC） and 17 cases were Crohn＇s disease （CD）.The standardized incidence of IBD was 3.14/100 000,of which the incidence of UC was 2.05/100 000 and CD was 1.09/100 000.According to the Montreal classification,among 31 UC patients,11（35.5%） were proctitis,13 （41.9%） were left-sided colitis and seven （22.6%）were pancolitis.Among the 17 CD patients,lesions of four cases were terminal ileum type （one complicated with upper gastrointestinal bleeding）,one case was colonic type and 12 cases were ileocolonic type （three cases complicated with upper gastrointestinal bleeding）.Eleven cases were non-stricturing and non-penetrating type,four cases were stricturing type and two cases were penetrating type.Conclusions The incidence of UC is 2.05/100 000 and CD is 1.09/100 000 in Zhongshan City of Guangdong Province.Left-sided colitis is most common in UC and ileocolonic type is the most common in CD.

关 键 词：炎症性肠病 结肠炎 溃疡性 克罗恩病 发病率 广东 

分 类 号：R574[医药卫生—消化系统]