周围神经吻合后神经生长因子-纤维蛋白胶包埋的临床观察  

Clinical observation of the effect of anastomosis of peripheral nerve embedded in fibrin glue containing nerve growth factor

作　　者：李波翰[1] 吴东进[1] 宋杨[1] 张程[1] 赵杰[1] 李德全[1] 张颖哲[1] 马胜忠[1] 高春正[1] 

机构地区：[1]山东大学第二医院骨科,济南250033

出　　处：《山东大学学报（医学版）》2013年第7期58-61,共4页Journal of Shandong University:Health Sciences

摘　　要：目的回顾分析周围神经损伤吻合后神经生长因子-纤维蛋白胶(NGF-FG)包埋的临床疗效。方法将2006年1月～2011年12月四肢周围神经损伤住院患者76例分为两组,2006～2007年为对照组(36例),2008～2011年为治疗组(40例)。对照组采用单纯外膜缝合,治疗组采用外膜吻合后加用NGF-FG包埋,分析感觉功能、运动功能、临床疗效和肌电图检查结果。结果对照组感觉功能评定有效率为75.00%,优良率为45.00%;治疗组有效率为86.96%,优良率为69.56%。对照组运动功能评定有效率为72.50%,优良率为45.00%;治疗组有效率为86.96%,优良率为65.22%。对照组临床疗效评定有效率为72.50%,优良率为47.50%;治疗组有效率为86.96%,优良率为67.39%。对照组肌电图恢复评定有效率为72.50%,优良率为47.50%;治疗组有效率为86.96%,优良率为69.57%。两组比较差异均有统计学意义(P<0.05)。结论用含有神经生长因子的纤维蛋白胶包埋离断周围神经的吻合口,能促进神经纤维功能的恢复,是修复周围神经损伤的一种较好方法。Objective To retrospectively analyze the clinical efficacy of anastomosis of peripheral nerve embedded by fibrin glue containing nerve growth factor. Methods The data of 76 hospitalized patients in our hospital from January 2006 to December 2011 were collected and analyzed. They were divided into two groups （ 2006-2007 for the control group, and 2008-2011 for the treatment group）. Epineurium anastomosis was used in the control group and the stoma of the nerve was coated by fibrin glue containing nerve growth factor in the treatment group. We analyzed the clinical effi- cacy by the results of the clinical manifestations and electromyogram（EMG）. Results The efficacy rate and excellence rate of sensory function assessment were 75.00% and 45.00% in the control group, and 86.96% and 69.56% in the treatment. The efficacy rate and excellence rate of motor function assessment were 72.50% and 45.00% in the control group, and 86.96% and 65.22% in the treatment group. The efficacy rate and excellence rate of clinical curative effect were 72.50% and 47.50% in the control group, and 86.96% and 67.39% in the treatment group. The efficacy rate and excellence rate of EMG recovery assessment were 72.50% and 47.50% in the control group, and 86.96% and 69.57% in the treatment group. The two groups had significant differences in all the above indicators（ all P 〈 0.05 ）. Conclusion The method of anastomosis of peripheral nerve embedded by fibrin glue containing nerve growth factor can promote the recovery of neural function, and it is a better way to repair injured peripheral nerve.

关 键 词：周围神经损伤 神经生长因子 纤维蛋白胶 神经修复 临床疗效 

分 类 号：R745[医药卫生—神经病学与精神病学]