早幼粒细胞白血病蛋白在Bowen病、皮肤鳞状细胞癌及皮肤基底细胞癌组织中的表达  

Expression of promyelocytic leukaemia protein in Bowen's disease, skin squamous cell carcinoma and basal cell carcinoma

作　　者：王琼玉[1] 马慧群[1] 王世捷[2] 马云云[1] 邹兴伟[1] 李蕊联[1] 

机构地区：[1]西安交通大学第二附属医院皮肤科,陕西西安710004 [2]西安交通大学环境与疾病基因教育部重点实验室//环境与地方病研究室,陕西西安710004

出　　处：《南方医科大学学报》2013年第7期1075-1077,1082,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(81171503);陕西省科技攻关项目(2008K12-02-5)~~

摘　　要：目的作为肿瘤抑制因子,早幼粒细胞白血病(PML)蛋白在Bowen病(BD)、皮肤鳞状细胞癌(SCC)及皮肤基底细胞癌(BCC)组织中的表达关系、以及PML蛋白与他们的临床预后关系不明,本研究旨在探讨PML蛋白在其中的作用机制。方法用免疫组化方法检测正常皮肤组织、BD、SCC及BCC皮损组织中PML蛋白的表达。结果正常人皮肤组织中,PML蛋白不表达(阴性);BCC皮损中,全层几乎无PML蛋白的表达(细胞核阳性率为8.69%,细胞质阳性率为4.35%);Bowen病及Ⅰ～Ⅱ级SCC皮损中,细胞核及细胞质均明显表达PML蛋白,且细胞核中的表达显著高于Ⅲ～Ⅳ级SCC。结论 PML蛋白的过度表达在鳞状细胞癌发病的早期阶段起关键作用,可能与SCC的发生和转移有关。Objective To investigate the expression of promyelocytic leukaemia （PML） protein of PML protein in Bowen＇s disease （BD）, skin squamous cell carcinoma （SCC） and basal cell carcinoma （BCC） and explore the role of PML in the pathogenesis of these diseases. Methods PML protein in normal skin tissues and lesions of Bowen＇s disease, SCC and BCC were detected with immunohistochemistry. Results Normal skin tissues did not express PML protein. In BCC, PML showed rather low expressions in the skin lesions （8.69% in cell nuclei and 4.35% in cytoplasm）. The lesions in BD and SCC （grade I and II） showed obvious overexpression of PML protein in the cell nuclei and cytoplasm, and its expression in the cell nuclei of these lesions was significantly higher than that in grade III-IV SCC. Conclusion PML protein may play an important role in the early stage of SCC, and its overexpression may contribute to the carcinogenesis and metastasis of SCC.

关 键 词：早幼粒细胞白血病蛋白 BOWEN病 鳞状细胞癌 基底细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]