孕中期妇女三联测定筛查唐氏综合征  

作　　者：谭忠伟[1] 冯建江[1] 黎彩鹏[1] 

机构地区：[1]江门市妇幼保健院检验科

出　　处：《当代医学》2013年第22期85-86,共2页Contemporary Medicine

摘　　要：目的探讨孕中期妇女(14～20周)外周血中三联检测——甲胎蛋白(AFP)和游离绒毛膜促性腺激素(F-βhCG)、游离雌三醇(uE3)检测,在胎儿唐氏综合征产前筛查中的作用。方法采用化学发光法检测孕妇血清AFP、F-βhCG与uE3浓度,结合孕妇年龄、孕周、体重,利用仪器配套软件计算胎儿患唐氏综合征的风险。结果筛查6700例孕妇,筛出唐氏综合征(含21-三体、18-三体、神经管缺陷)高风险孕妇325例,可疑阳性率4.85%;经产前诊断检查,最终确认,21-三体患儿18例、18-三体患儿7例;神经管缺损17例。结论孕妇血清标记物检测能有效地筛出唐氏儿,降低缺陷人口的出生。Objective To investigate the effect of screening for Down Syndrome（DS）by detecting serum AFP、unconjugateg estriol（uE 3） and F-β hCG in pregnant women（14～20 weeks）.Methods Used a method based on detecting maternal serum AFP,uE 3 and F-β hCG concentrations in pregnant women（14-20 weeks）,and combination with maternal age and gestational age.Pregnant woman at risk for fetal DS were identified by analyses of special computer software.Results Among 6700 pregnant woman 325 case（4.85%） were at high risk for DS.After prenatal diagnosis examination,finally confirmed,21-trisomysyndrome in 18 cases;18-trisomysyndrome in 7 cases;neural tube defects of 17 cases.Conclusion Prenatal screening can reduce the need for invasive prenatal diagnosis,decreasing the birth rate of DS.

关 键 词：产前筛查 游离绒毛膜促性腺激素 甲胎蛋白 游离雌三醇 唐氏综合征 

分 类 号：R714.5[医药卫生—妇产科学]