老年痴呆病的发病机制及临床药物治疗分析  

作　　者：梁汉周[1] 梁雁[1] 黄波[1] 

机构地区：[1]高州市人民医院神经内科

出　　处：《当代医学》2013年第22期150-151,共2页Contemporary Medicine

摘　　要：目的探讨老年痴呆病的发病机制及临床采用中西医结合药物治疗效果。方法就诊的50例老年痴呆病患者随机分为观察组和对照组,各25例。对照组临床给予西药吡拉西坦片,每天3次,每次2片(0.8g)进行治疗,观察组在对照组的基础上给予自拟中药补肾益智汤治疗,观察两组患者治疗前后的效果。结果对照组显效11例,有效7例,好转5例,无效7例,总有效率为76.67%;观察组30例患者种有效显效18例,有效6例,好转4例,无效2例,总有效率为93.33%。观察组与对照组比较差异有统计学意义(P<0.05)。结论老年痴呆病发病机制主要与基因突变、胆碱能缺失等有关,临床采用中西医结合治疗总有效率高,效果显著,值得临床推广使用。Objective To investigate the pathogenesis of alzheimer＇s disease and clinical effects of drug treatment.Methods In that hospital,50 cases of alzheimer＇s disease patients were divided into the observation group and the control group with 25 cases in each group.The control group treated with piracetam in clinical treatment,three times a day,two tablets each time（0.8g） the observation group was given Chinese medicine Bushen Yizhi decoction based on control group and the effect were observed before and after treatment in two groups.Results In the control group 11 cases were excellent,effective in 7 cases,5 cases were improved,7 cases were invalid,the total efficiency rate was 76.67%,the observation group 30 cases were excellent,effective in 18 cases,effective in 6 cases,4 cases were improved,2 cases were ineffective,the total effective rate was 93.33%,there was significant difference between treatment group and control group（P0.05）.Conclusion Alzheimer＇s disease pathogenesis and gene mutation,cholinergic deletion,Clinical use of Integrated Chinese and Western medicine treatment the total effective rate is high,significant effect,worthy of clinical use.

关 键 词：老年痴呆病 发病机制 药物治疗 效果 

分 类 号：R749.16[医药卫生—神经病学与精神病学]