胸腺五肽局部应用对口腔溃疡患者血清IL-2及SOD的影响  

Effects of topical administration of thymopentin on the serum level of IL-2 and SOD in patients with recurrent oral aphthous ulcer

作　　者：刘捷[1] 迟强[1] 栾中山[1] 杨志[1] 

机构地区：[1]中国人民解放军第215医院,大连116041

出　　处：《实用口腔医学杂志》2013年第4期539-541,共3页Journal of Practical Stomatology

基　　金：全军后勤科研计划课题(编号:CSY12J012)

摘　　要：目的:考察口腔溃疡患者应用胸腺五肽局部治疗后,血清白细胞介素-2(IL-2)和超氧化物歧化酶(SOD)的变化情况。方法:选择本院门诊确诊的口腔溃疡期患者80例,随机分为胸腺五肽治疗组40例,冰硼散治疗组40例。同时另选40例同期在年龄、性别方面差异无显著性的本院门诊健康体检者作为正常对照组。观察患者的溃疡愈合情况,记录疼痛缓解情况,测定各组在初诊和复诊时血清IL-2和SOD的含量。结果:胸腺五肽治疗3 d后,血清IL-2和SOD有明显提高(P<0.01),但仍低于正常对照组。冰硼散组治疗前后患者血清IL-2和SOD水平无明显变化(P>0.05)。胸腺五肽组疼痛缓解率和溃疡愈合率分别达到87.5%和82.5%,而冰硼散组分别为60%和45%。结论:胸腺五肽治疗口腔溃疡能够有效缓解疼痛和加速愈合,这可能与提高血清IL-2和SOD有关。Objective：To investigate the effects of topical administration of thymopentin on the serum level of IL-2 and SOD in patients with recurrent oral aphthous ulcer（ROU）.Methods： 80 cases of ROU and 40 age-and sex-matched healthy controls were included in the study.All the cases were divided into two groups： 40 were treated by topical administration of thymopentin and another 40 by Bingpeng powder.Ulcer healing and pain relief in the patients were observed.Serum IL-2 and SOD levels were measured before and after treatment.Results： The serum levels of IL-2 and SOD in thyonopentin treated patients were increased 3 days after treatment（P〈0.01）,but lower than those in the healthy controls（P〈0.05）.The serum levels of IL-2 and SOD in bingpeng powder treated patients were unchanged（P〈0.05）.87.5% and 82.5% cases obtained pain relief and ulcer healing in thymopentin group,whereas 60% and 45% in bingpeng powder group,respectively（P〈0.01）.Conclusion： Thymopentin is effective in the pain control and promotion of ROU healing,and the effects might be related to elevateion serum IL-2 and SOD.

关 键 词：胸腺五肽 口腔溃疡 白细胞介素-2 超氧化物歧化酶 

分 类 号：R781.5[医药卫生—口腔医学]