血浆性激素水平和绝经前女性患乳腺癌危险性的关系  

Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer among Premenopausal Women

作　　者：马瑞兰[1] 张海琛[1] 李国权[1] 徐晓颖[1] 邹丽娟[1] 

机构地区：[1]大连医科大学附属第二医院肿瘤放疗科,辽宁大连116023

出　　处：《肿瘤防治研究》2013年第7期667-670,共4页Cancer Research on Prevention and Treatment

摘　　要：目的评价血浆类固醇性激素水平与绝经前女性患乳腺癌危险性的关系。方法采用放射免疫法测定75例绝经前女性乳腺癌病例和78例匹配对照的血浆雌二醇(E2)、孕酮(P)及睾酮(T)水平,并应用条件Logistic回归分析绝经前女性血浆E2、P、T水平与患乳腺癌危险性的关系。结果 (1)病例组血浆E2和T水平均显著高于对照组;病例组血浆P水平低于对照组,但差异无统计学意义。(2)以下四分位数(P25)为非暴露参考,血浆P上四分位数(P75)水平调整OR(95%CI)为0.43(0.20～0.85),趋势P=0.023;血浆T上四分位数(P75)水平调整OR为3.63(1.82～7.45),趋势P=0.015;血浆E2上四分位数(P75)水平调整OR为2.48(1.27～5.14),但差异无统计学意义,趋势P=0.270。结论血浆T水平与绝经前女性患乳腺癌的危险性呈正相关,血浆P水平与绝经前女性患乳腺癌的危险性呈负相关。Objective To estimate the association of plasma sex steroid hormone levels with risk of breast cancer among premenopausal women. Methods By use of case-control study, levels of plasma estradiol （E2）,testosterone （T） and progesterone （P） were measured in 75 premenopausal women with breast cancer patients and 78 matched control subjects by radioimmunoassay during the follicular phase of their menstrual cycles. Conditional logistic regression models , controlling for breast cancer risk factors, were used to examine their associations with breast cancer risk. All statistical tests were two-sided. Results （1）The plasma levels of Fa and T of case group were significantly higher than those of control group. The plas- ma level of P was lower than that of the control group, but the resuts as not statistically significant. （2）Increased risks of breast cancer were positively associated with elevated plasma concentration of testosterone（adjusted odds ratio[OR] for highest versus lowest quartile = 3. 63, 95 confidence interval[95 CI-] = 1.82 - 7. 45, P= 0. 015） . Elevated serum progesterone concentrations was associated with a statistically significant reduction in breast cancer risk（adjusted OR = 0. 43, 95%oCI = 0. 20 - 0. 85, P= 0. 023）. Higher level of estradiol was associated with modest, non-statistically significant increase in risk of breast cancer（adjusted OR = 2. 48, 95% CI = 1.27 - 5. 14, P = 0. 270）. Conclusion Results suggested that high plasma level of testosterone was positively associated with breast cancer risk, while high plasma level of progesterone was negatively associated with breast cancer risk in premenopausal women.

关 键 词：乳腺癌 危险因素 类固醇性激素 绝经前女性 

分 类 号：R730.231[医药卫生—肿瘤]