KAI-1基因在胃癌组织中的表达及其临床病理意义  

Expressions of KAI-1 gene in gastric cancer and their pathological significances

作　　者：段建峰[1] 刘晓晨[1] 豆发福[1] 郑明华[1] 李光华[1] 周亚东[1] 丁建龙[1] 刘李[1] 赵喜荣[1] 

机构地区：[1]西安交通大学医学院附属3201医院普外科,陕西汉中723000

出　　处：《中国现代普通外科进展》2013年第7期527-529,共3页Chinese Journal of Current Advances in General Surgery

基　　金：陕西省卫生厅科研基金资助项目(2010H38)

摘　　要：目的:探讨KAI-1基因在胃癌组织中的表达和临床意义,以及与病理类型的联系。方法:选取2008年3月—2011年3月行手术治疗的胃癌患者40例和同期手术治疗的非胃癌疾病患者20例的胃石蜡标本,采用免疫组织化学染色SABC法检测癌组织及胃良性病变组织中的KAI-1基因的表达。结果:KAI-1基因在胃癌组织中的表达阳性率明显低于胃良性病变组织(P<0.05)。且这种表达差异体现在不同的胃癌组织类型中。结论:KAI-1基因的低表达可能是导致肿瘤侵袭力增强和易发生转移的危险因素之一。Objective： To explore the expressions of KAI-1 Gene in Gastric Cancer and Their Pathological Significances. Methods： The forty samples of Gastric Cancer were collected from 2008 to 2011 and 20 cases Gastric samples of non Gastric cancer were collected as control. The expres-sions of KAI-1 Gene were detected by immunohistochemical strept-avidin-biotin complex（SABC） method. Results： The positive rates of KAI-1 Gene in Gastric Cancer tissues were lower than the Gastric tissues of non Gastric cancer,and the difference were shown the pathological type of Gastric Cancer. Conclusion： The low expression of KAI-1 Gene in Gastric Cancer maybe is one of dan-gerous factor caused metastasis easily.

关 键 词：KAI-1基因 胃肿瘤 病理类型 

分 类 号：R735.2[医药卫生—肿瘤]