IGF-Ⅱ和IGF-ⅠR及IGFBP-3在结直肠癌组织中的表达及其临床意义  

Expression and biological significance of IGF-Ⅱ and IGF-ⅠR and IGFBP-3 in colorectal cancer

作　　者：鞠昕丽[1] 初蕾蕾[2] 杨阅楼 宋明全[2] 崔艳欣[2] 林惠忠[4] 姜相君[2] 

机构地区：[1]大连医科大学,辽宁大连116044 [2]青岛大学医学院附属青岛市市立医院消化内二科,山东青岛266011 [3]青岛市开发区第一人民医院消化内科,山东青岛266555 [4]青岛大学医学院附属青岛市市立医院普外科,山东青岛266011

出　　处：《中国现代普通外科进展》2013年第7期562-565,共4页Chinese Journal of Current Advances in General Surgery

基　　金：青岛市科技局资助项目(10-3-3-4-6-nsh)

摘　　要：目的 :检测IGF-Ⅱ、IGF-ⅠR、IGFBP-3在结直肠癌中的表达,探讨其表达在结直肠癌的早期诊断中的价值。方法:应用免疫组织化学SP法分别检测结直肠癌、结直肠腺瘤、炎性息肉及正常结肠黏膜组织中IGF-Ⅱ、IGF-ⅠR、IGFBP3的表达情况。结果:1)IGF-Ⅱ、IGF-ⅠR、IGFBP-3在结直肠癌组织中表达的阳性率均高于结直肠腺瘤、炎性息肉和正常组织,且具有统计学意义(P<0.05);2)IGF-Ⅱ、IGF-ⅠR、IGFBP-3在炎性息肉和管状腺瘤、混合型腺瘤及绒毛状腺瘤中表达阳性率依次增高,但差异无统计学意义(P>0.05);3)IGF-Ⅱ、IGF-ⅠR、IGFBP-3与患者的年龄、性别、吸烟情况、有无饮酒史及肿瘤家族史等指标之间均无统计学意义(P>0.05);4)IGF-Ⅱ、IGF-ⅠR、IGFBP-3间的表达呈正相关。结论:结直肠癌患者血清IGF-Ⅱ、IGF-ⅠR、IGFBP-3水平明显升高可能与结直肠癌的发生相关。[ABSTRACT] Objective： To detect the expression of IGF- Ⅱ ,IGF- I R and IGFBP-3 in colorectal cancer and find its value in diagnosis of early colorectal cancer. Methods： The expression of IGF- Ⅱ , IGF-IR and IGFBP-3 was analyzed by immunohistochemical SP method in 40 cases of col-orectal cancer, 50 cases of colorectal adenomas, 20 cases of inflammatory polyps and 20 cases of normal colon tissue. Results： 1）The positive rates of IGF- Ⅱ , IGF-IR and IGFBP-3 in colorectal cancer were higher than the colorectal adenomas, inflammatory polyps and normal tissue, and there were significant differences （P〈0.05）. 2）The positive rates of IGF- Ⅱ, IGF-IR and IGFBP-3 in in- flammatory polyp,tubular adenoma, mixed adenoma and villous adenoma were gradually increased, but they had no significant differences（P〉0.05）. 3）There were no significant differences in age,gen-der of patients, smoking,drinking and history of tumor. 4）The expressions of IGF- Ⅱ, IGF-IR, IGF-BP-3 were positively correlated. Conclusion： IGF- Ⅱ, IGF-IR and IGFBP-3 may be associated with the occurrence of colorectal cancer.

关 键 词：结直肠肿瘤 胰岛素样生长因子Ⅱ 胰岛素样生长因子IR 胰岛素样生长因子结合蛋白-3 

分 类 号：R735.3[医药卫生—肿瘤]