不同佐剂制备的H9N2亚型禽流感(SS株)灭活疫苗的免疫效果和安全性评价  

Immune Efficacy and Safety Evaluation of H9N2 Avian Influenza(Strain SS) Inactivated Vaccine Prepared by Different Oil Adjuvants

作　　者：仇微红 叶贺佳 李敏 王鑫 梁昭平[1,2] 罗开健[1,2] 

机构地区：[1]广州市华南农大生物药品有限公司,广东广州511300 [2]华南农业大学兽医学院,广东广州510642

出　　处：《中国家禽》2013年第14期19-21,共3页China Poultry

基　　金：农业科技成果转化资金项目(2011GB2E000005);国家肉鸡产业技术体系项目(nycytx-42-G3-03)

摘　　要：利用8种不同佐剂制备了16种H9N2亚型禽流感(SS株)灭活疫苗,对疫苗的物理性状、安全性、免疫效力及疫苗吸收情况进行检验,结果表明:疫苗外观、剂型、黏度均符合国家标准,物理性状稳定;接种SPF鸡后3周,16种疫苗HI抗体效价均超过11log2;剖检显示,大多数疫苗残留较少。The physical properties, safety, immune efficacy and vaccine residual, of 16 kinds of H9N2 avian influenza （Strain SS） inactivated vaccines prepared by 8 kinds of different oil adjuvants were examined, and the appearance, dosage form, stability and viscosity of vaccines were accorded with national standard. The results showed that HI antibody titer of 16 kinds of avian influenza inactivated vaccines were all exceeded 11 log2 when injected SPF chicken after 3 weeks,the results of H9N2 vaccine residual experiment confirmed that most of vaccine had residual.

关 键 词：灭活疫苗 黏度 HI抗体 

分 类 号：S852.659.5[农业科学—基础兽医学]