MR扩散加权及灌注成像对肝癌介入治疗疗效的研究进展  

Progress of diffusion-weighted imaging and perfusion-weighted imaging in evaluation on therapeutic efficiency of transcatheter arterial chemoembolization of hepatocellular carcinoma

作　　者：马霄虹[1] 周纯武[1] 

机构地区：[1]北京协和医学院中国医学科学院肿瘤医院影像诊断科,100021

出　　处：《国际医学放射学杂志》2013年第4期344-348,共5页International Journal of Medical Radiology

基　　金：中央级公益性科研院所基本科研业务费专项资金(JK2012B05)

摘　　要：对于临床不能手术切除的肝癌,其经导管肝动脉化疗栓塞(TACE)是主要的治疗方法。TACE术后疗效的早期、准确及有效判断,直接决定病人的后续治疗及预后。以MR扩散加权成像(DWI)、MR灌注加权成像(PWI)为代表的反映微观变化的MR功能成像技术可以先于肿瘤形态学的变化,通过反映细胞密度或肿瘤血管密度,从而帮助早期判断肿瘤治疗的反应。就MRDWI及PWI评价原发肝癌TACE治疗疗效的研究进展进行综述。Transcatheter arterial chemoembolization （TACE） is the main treatment of interventional therapy for advanced hepatocellular carcinoma （HCC）. Early following-up and accurate evaluation after TACE directly determine the follow-up treatment and prognosis of patients. At present, functional MRI, including diffusion-weighted imaging （DWI） and perfusion- weighted imaging （PWI）, can reflect the microscopic changes in tumor before morphologic changes. DWI and PWI provide a new examination for evaluation of HCC, which can detect the change of cell density or tumor vascular density and can early evaluate the tumor response to treatment. The application of DWI and PWI in evaluation of HCC was reviewed in this article.

关 键 词：肝癌 磁共振成像 扩散加权成像 灌注成像 经导管肝动脉化疗栓塞 

分 类 号：R739.41[医药卫生—肿瘤]