脑膜血管瘤病临床病理观察  

Clinicopathological features of meningioangiomatosis

作　　者：葛畅[1] 王鲁平[1] 许春伟[1] 刘志钦[2] 

机构地区：[1]安徽医科大学临床学院北京军区总医院病理科,北京100700 [2]安徽医科大学临床学院北京军区总医院放射诊断科,北京100700

出　　处：《诊断病理学杂志》2013年第7期414-418,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨脑膜血管瘤病(MA)的临床病理学特点。方法观察1例MA患者的临床表现、MRI及组织学特点,并复习相关文献。结果患者女性,23岁。因发作性癫1年余入院。MRI示右顶叶皮质内约2.6 cm×2cm大小团片状短T2、长T1及等T1异常信号。镜检示脑膜上皮细胞和纤维母细胞样梭形细胞增生,并围绕在皮质内的小血管周围,伴有钙化和砂砾体形成,病灶内可见残存的神经元和胶质细胞。免疫组化显示增生的梭形细胞vimentin(+);血管内皮细胞CD34(+);残留的胶质细胞GFAP和Olig-2(+)。结论 MA为脑皮质良性病变,预后良好。形态学上MA需与侵袭性脑膜瘤、神经节细胞胶质瘤、动静脉血管畸形等鉴别。Objective To investigate the clinical and pathological features of meningioangiomatosis（MA）.Methods A case of MA was reported.The clinical manifestations,MRI,histological features and pathologic diagnosis were analyzed,with review of related literatures.Results Female patient,23 years old,admitted to hospital due to paroxysmal epilepsy more than 1 year.MRI showed short T2,long T1 and equivalent T1 abnormal signal in right parietal cortex,about size of 26×20 mm.The pathological characteristics of this case included the epithelial cells and fibroblast-like fusiform cells proliferation surrounding the small blood vessels within the cortex,accompanied by calcification and psammoma body,and the intralesional visible remnants of neurons and glial cells.Immunohistochemical study demonstrated the spindle cells were positive for vimentin,vascular endothelial cell positive for CD34,and residual glial cells were positive for GFAP and Olig-2.Conclusions This case is the sporadic type of MA,with a good prognosis.Morphologically,it is needed to differentiate MA from invasive meningiomas,gangliocytoma,arteriovenous vascular malformation.

关 键 词：脑膜血管瘤病 免疫组化 临床病理 鉴别诊断 

分 类 号：R737.3[医药卫生—肿瘤]