蛤壳油糊外用对大小鼠烫伤模型的影响  

External application effect of clam shell oil paste on scalded mice and rats

作　　者：李瑞奇[1] 缪君娴[1] 白明[1] 苗明三[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中华中医药杂志》2013年第8期2256-2259,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金："十一五"国家科技支撑计划(No.2008BAI53B09);郑州市科技攻关(No.10PTGS485-21)~~

摘　　要：目的:探讨外用蛤壳油糊对大小鼠烫伤模型的影响。方法:动物背部去毛,次日腹腔注射水合氯醛麻醉,将大鼠去毛的背部皮肤浸入80℃恒温水浴中持续10s,使之造成大鼠烫伤模型,小鼠去毛的背部皮肤浸入90℃恒温水浴中持续6s,使之造成小鼠烫伤模型,观察大、小剂量文蛤油糊,大、小剂量青蛤油糊对动物烫伤皮肤面积变化的影响和病理组织变化的影响。结果:大、小剂量文蛤油糊组,大、小剂量青蛤油糊组动物烫伤皮肤面积比用药前均显著减小(P<0.01),且能显著改善烧烫伤的病理损伤(P<0.01)。结论:外用蛤壳油糊对大小鼠烫伤有较好的治疗作用。Objective： To explore the external curative effect of clam shell oil paste on scalded mice and rat model. Methods： Removing the back hair of animals, and intraperitoneal injection of chloral to anaesthetize animals on the next day, then immersing the animals＇ back skin into the thermostat water bath which was 80 or 90 degree Celsius for 10 seconds or 6 seconds to make them be scalded, and observing the changes of scalded skin area and pathological changes of Meretrix meretris Linnaeus oil paste and Cyclina Sinensis Gmelin oil paste on the scalded skin. Results： Meretrix meretris Linnaeus oil paste and Cyclina Sinensis Gmelin oil paste could significantly reduce the scalded skin area （P〈0.01）, and significantly improve the burned and scalded injury （P〈0.01）. Conclusion： The external application of the clam shell oil paste had a good curative effect on scalded mice and rat model.

关 键 词：蛤壳油糊 外用 烫伤 

分 类 号：R-332[医药卫生]