晚期结直肠癌中医疗效评价方法的建立  

Evaluation method establishment for TCM response criteria in treating advanced colorectal cancer

作　　者：朱尧武[1] 何小宁[2] 杨宇飞[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2013年第8期2353-2356,共4页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:建立中医综合疗效标准模型,与实体肿瘤疗效评价标准(RECIST)在中医及中西医结合治疗晚期结直肠癌中的预后作用进行比较。方法:采用回顾性连续病例研究方法,将影响晚期结直肠癌预后的多个因素进行Cox回归分析,建立晚期结直肠癌中医综合疗效标准模型,用Kaplan-Meier法判断两种疗效标准对晚期结直肠癌的预后作用。结果:89例晚期结直肠癌患者纳入研究,根据Cox多因素回归分析,中医综合疗效标准的评价指标为瘤体大小、Karnofsky评分、体质量及主症变化4项。中医综合疗效标准评价为有效与恶化的中位生存期分别为25.00与6.00个月,差异有统计学意义(χ2=33.21,P=0.000)。结论:中医综合疗效标准用于评价中医及中西医结合治疗晚期结直肠癌有较好的预后作用。Objective： The comprehensive TCM response criteria was built up. It was compared with response evaluation criteria in solid tumors （RECIST） in evaluating the efficacy in advanced colorectal cancer treated with TCM or TCM combined with western medicine. Methods： Using a retrospective case study method, the Cox regression analysis was used to analyze the clinical factors that affected the prognosis of advanced colorectal cancer, then the comprehensive TCM response criteria was built up. Kaplan-Meier survival analysis was used to compare two criteria for advanced colorectal cancer prognosis. Results： 89 patients with advanced colorectal cancer were included in the study. According to Cox regression analysis, changes in tumor size, KPS, weight and main symptoms were the four factors that were included in the comprehensive TCM response criteria. Evaluating with the TCM criteria, the survival curve of effective cases was significantly different from that of progressive cases （MST 25.00 vs 6.00, Z2=33.21, P=0.000 ）. Conclusion： The TCM criteria can better reflect the prognosis of advanced colorectal cancer treated by TCM or TCM combined with western medicine than RECIST.

关 键 词：晚期结直肠癌 中医综合疗效标准 实体肿瘤疗效评价标准 生存时间 

分 类 号：R735.3[医药卫生—肿瘤]