脑白质疏松症与进展性脑卒中的关系研究  

Research on relationship between leukoaraiosis and progressing stroke

作　　者：肖莉[1] 王庆松[1] 王俊[1] 潘先芳[1] 彭芳[1] 

机构地区：[1]成都军区总医院神经内科,成都610083

出　　处：《中国实用神经疾病杂志》2013年第14期3-6,共4页Chinese Journal of Practical Nervous Diseases

摘　　要：目的研究分析脑白质疏松症与进展性脑卒中的关系。方法选取2009-01—2012-01入院治疗的进展性脑卒中患者88例为实验组,并选取同期入院治疗的非进展性脑梗死病人98例作为对照组。所有患者均抽取空腹12h肘静脉血检测空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血压、意识水平、肢体功能等指标,并均接受T1、T2、液体恢复反转序列(FLAIR)、弥散加权成像序列的磁共振检查,根据FLAIR影像评判脑白质疏松,并分析脑血管狭窄情况及脑白质疏松是否增加了进展性脑梗死的风险。结果 2组患者在年龄、性别、饮酒吸烟史以及血压、血糖、血脂方面发病率均无明显差异。其中第1天2组患者的神经功能没有显著差异,但在第7天,实验组的神经功能水平显著低于对照组。Fazekas分级中实验组轻度46.59%,中度36.36%,重度17.05%,合并LA患者47例(53.41%);对照组轻度为83.67%,中度16.33%,重度无,合并LA患者16例(16.33%)。实验组脑血管狭窄52例(59.09%),对照组32例(32.65%)。结论脑白质疏松症在一定程度上可以提示进展性脑卒中,且脑血管狭窄在进展性脑卒中的风险也颇高。Objective To analyze the relationship between leukoaraiosis and progressing stroke. Methods 88 patients with progressing stroke treated in our hospital from January 2009 to January 2012 were selected as the experiment group, and 98 patients with NPCI treated in our hospital simultaneously were selected as the control group. All patients were extracted hollow 12 h cubits venous blood to test fasting the blood glucose, total cholesterol, triglyceride, high--density lipoprotein and low--density lipoprotein, and meanwhile, the blood pressure, level of consciousness and limb function were also tested. All patients received magnetic resonance spectroscopy of T1, T2, FLAIR and diffusion weighted imaging. We evaluated the degree of leukoaraiosis according to FLAIR image, and then analyzed the risk of cerebrovascular stenosis situation and whether or not leukoaraiosis increasing the progressive cerebral infarction. Results There was no difference between two groups of patients in TC, TG, HI）L, LDL, age, sex, drink, smoking habit and FBG level; The FBG level of experiment group was higher than that of control group on the seventh day. The consciousness level and limb function of control group was better than that of ex- periment group. The Fazekas classification was： mild （46.59 %）, moderate （36.36 % ）, severe （17.05 %） and combined with LA（47 patients 53.41%）in treatment group, and mild （83.67%）, moderate （16.13%）, severe （0%） and combined with IrA （16 patients 16.33 % ）in control group; Patients with cerebrovascular stenosis were 59.09 % （52 cases） in the experiment group and 32.65% （32 cases） in the control group. Conclusion Leukoaraiosis can indicate the degree of progress cerebral stroke to some extent,and cerebrovascular stenosis is quite high in the progress of cerebral stroke risk.

关 键 词：脑白质疏松症 进展性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]