脑胶质瘤术后联合放化疗效果观察  

Observation on the Effect of Postoperative Radiotherapy Combined with Chemoradiotherapy in Treatment for Brain Gliomas

作　　者：詹辉[1] 李林繁[1] 

机构地区：[1]广东省高州市人民医院,广东高州525200

出　　处：《中国医学创新》2013年第21期107-109,共3页Medical Innovation of China

摘　　要：目的:探讨脑胶质瘤术后放射治疗联合替莫唑胺化疗的治疗效果。方法:选取2008年1月-2010年12月本院收治的WHOⅢ～Ⅳ级脑胶质瘤患者54例,随机分为A组和B组各27例,两组均在手术切除肿瘤后给予放射治疗,B组进行放射治疗,A组在放射治疗的基础上使用替莫唑胺化疗。对比两组的近期疗效、生存率和不良反应。结果:A组有效率为77.8%;高于B组的48.1%,比较差异有统计学意义(P<0.05);两组的1年生存率比较差异无统计学意义(P>0.05),A组的2年生存率为48.1%,高于B组的22.2%,比较差异有统计学意义(P<0.05)。A组的不良反应与B组比较,差异无统计学意义(P>0.05)。结论:脑胶质瘤术后联合放化疗能有效提高治疗效果,延长患者的生存期,值得推广应用。Objective： To explore the therapeutic efficacy of brain glioma treated with postoperative radiotherapy combined with temozolomide chemotherapy.Method： 54 patients with WHO grade ~I - IV gliomas from January 2008 to December 2010 were divided into group A and group B, with 27 patients in each group.Both groups were given radiotherapy after surgical resection of the tumor.Group B was given radiotherapy, group A was given temozolomide chemotherapy on the basis of radiotherapy.The short-term effect, survival and adverse reactions of two groups were compared.Result： The effective rate of group A （ 77.8% ） was higher than that of group B （ 48.1% ） .The difference was statistically significant between the two groups （ P〈0.05 ） . The one-year survival rates of the two groups showed no significant difference （ P〉0.05 ） .The two-year survival rate of group A was 48.1%, which was higher than the 22.2% of group B, the difference was statistically significant （ P〈0.05 ） .Compared the adverse reactions of group A with group B, the difference was not statistically significant （ P〉0.05 ） .Conclusion： Postoperative radiotherapy combinecl with chemotherapy treating glioma can effectively improve the therapeutic effect and prolong the survival, should be widely applied.

关 键 词：脑胶质瘤 放射治疗 替莫唑胺 

分 类 号：R739.4[医药卫生—肿瘤]