广州地区不同胎龄早产儿出生时骨定量超声值测定  

Quantitative ultrasound bone measurements of different gestational age premature infants at birth in Guang- zhou zone

作　　者：瞿柳红[1] 李思涛[2] 庄桂英[1] 徐庆活 杨文欢[1] 肖昕[1] 

机构地区：[1]广州市花都区妇幼保健院新生儿科,510800 [2]中山大学附属第六医院儿科

出　　处：《中华实用儿科临床杂志》2013年第14期1077-1079,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：广东省科技计划项目（00728411120223054）

摘　　要：目的测定广州地区不同胎龄早产儿出生时的骨定量超声值，并与高加索白人种早产儿比较，了解广州地区早产儿骨骼发育的状况，评价定量超声技术的实用性。方法采用以色列Sunliight公司生产的Omnisense定量超声仪，对2010年6月至2012年6月在广州市花都区妇幼保健院出生的不同胎龄的早产儿进行左侧胫骨声波速度（SOS）测量，并与高加索白人种进行比较。结果广州地区出生的1039例不同胎龄早产儿根据胎龄分为A、B、C、D组（≤30周、30＋1～32周、32＋1～34周和34＋1～36＋6周4组）。4组早产儿出生时所测得的SOS值分别为（2892．05±139．17）m／s、（2936．84±137．87）m／s、（2966．65±116．60）m／s和（2988．63±120．74）m／s，SOS值随胎龄增加而增加，差别有统计学意义（F=15．758，P=0．000），但各组中男女童之间SOS值无明显差异（F=2．665，P=0．103）。广州地区不同胎龄的早产儿出生时SOS值的差距（定义为z值）与高加索白人种比较差异无统计学意义（P=0．117），男女比较差异亦无统计学意义（F=3．494，P=0．062）。结论早产儿SOS值随早产儿成熟度增加而升高；广州地区的不同胎龄早产儿出生时骨强度与高加索白人种无明显莘距：骨定量超声技术可用于临床评价早产儿骨发育情况。Objective To measure the values of quantitative ultrasound（QUS） of different gestational age pre- term infants at birth in Guangzhou area, and compare them with the values of Caucasian preterm infants in order to get insight into the bone development status of preterm infants in Guangzhou area and to evaluate the practicability of QUS. Methods The Omnisense quantitative ultrasound produced by Israel Sunlight company was used to measure the bone speed of sound（SOS） of left tibia of preteim infants born between Jun. 2010 and Jun. 2012 in Maternity and Children Health Hospital of Huadu District in Guangzhou, and the values of SOS of Caucasian preterm infants was compared. Re- suits There were totally 1039 preterm infants born in Guangzhou area involved in this study, and they were divided in- to group A, B, C, D by gestational ages： ≤ 30 weeks,30 ＋1 -32 weeks,32 ＋1 -34 weeks,34 ＋1 - 36 ＋6 weeks. The values of SOS of each group at birth were（2892.05± 139.17） m/s, （2936.84 ± 137.87） m/s, （2966.65 ± 116.60） m/s and （ 2988.63 ± 120.74） m/s, separately, and with the increase of gestational age, and there was significant difference of SOS between different gestational age groups （F = 15. 758, P = 0. 000 ）. But there was no significant difference of SOS between male and female（F = 2. 665, P = 0. 103 ）. Compared with Caucasian preterm infants, the SOS value gap （ de- fined as the Z value ） of preterm infants of different gestational age in Guangzhou area was no significant difference （P = 0.117 ）, and there was no significant difference between male and female （ F = 3. 494, P = 0. 062 ）. Conclusions The value of SOS of preterm infants was higher with the increase of maturity of preterm infants. There was no significant difference of SOS between Guangzhou preterm infants and Caucasian preterm infants. And QUS is suitable for clinical e- valuation of bone development status of preterm infants.

关 键 词：骨定量超声技术 声波速度值 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科] R445.1[医药卫生—临床医学]