邻氯苯甲腈的新合成法  

A New Synthetic Route Toward o-Chlorobenzonitrile

作　　者：朱益忠[1] 张喜全[1] 刘飞[1] 顾红梅[1] 朱海亮[2] 

机构地区：[1]江苏正大天晴药业股份有限公司,南京210042 [2]南京大学生命科学学院医药生物技术国家重点实验室,南京210093

出　　处：《应用化学》2013年第8期971-973,共3页Chinese Journal of Applied Chemistry

基　　金：江苏省博士后基金

摘　　要：以邻氯溴苯为起始原料,选用K4[Fe(CN)6]为氰基化试剂,Pd/C催化反应制得邻氯苯甲腈。考察了温度、碱、催化剂的用量和原料比等对反应的影响,确定了较佳反应条件。邻氯溴苯转化率达98.5%,产物邻氯苯甲腈得率95.1%。o-Chlorobenzonitrile was prepared from the cyanization reaction of o-chlorobromobenzene using potassium ferrocyanide as cyanating agent and Pd/C as a catalyst. The reaction conditions were optimized through investigating the reaction temperature, base, the amount of catalyst, the ratio of reactants. The conversion of the o-chlorobromobenzene to target product could reach 98.5% and the yield of o-chlorobenzonitrile was 95.1%.

关 键 词：邻氯溴苯 K4[Fe(CN)6] 氰基化反应 

分 类 号：O621.2[理学—有机化学]