艾司西酞普兰联合舒必利对抑郁症患者疗效和血清白细胞介素-6的影响  

Efficacy of escitalopram combined with sulpiride in patients with depression and its influence on serum IL-6

作　　者：周立发[1] 

机构地区：[1]山东省青州荣军医院,262500

出　　处：《中国实用医刊》2013年第15期49-51,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨艾司西酞普兰联合舒必利对抑郁症患者疗效和血清白细胞介素-6（IL-6）的影响。方法90例抑郁症患者随机分为两组，观察组50例，采用艾司西酞普兰联合舒必利治疗；对照组40例，采用艾司西酞普兰治疗，共治疗6周。分析疗效并测定血清IL-6变化。结果对照组患者治疗总有效率为67．5％，观察组患者治疗总有效率为86．0％。观察组患者治疗总有效率明显高于对照组，组间比较差异有统计学意义（P〈0．05）。治疗后2、4、6周对照组与观察组患者HAMD评分较治疗前均明显下降，差异有统计学意义（P〈0．01）；同时观察组患者同期HAMD评分明显低于对照组，组间比较差异有统计学意义（P〈0．01）。两组治疗前血清IL-6比较差异无统计学意义（P〉0．05），治疗后比较差异有统计学意义（P〈0．01）。结论采用艾司西酞普兰联合舒必利可以多种途径改善抑郁症患者病情。Objective To investigate the effect of escitalopram combined with sulpiride in pa- tients with depression and its influence on serum interleukin-6 （IL-6）. Methods Ninety patients with depression were randomly divided into two groups, the observation group（50 cases） and the control group （40 cases）. Patients in observation group were treated with escitalopram combined with sulpiride and pa- tients in control group were treated with escitalopram. They were treated for six weeks, and then detectedthe level of IL-6 and compared the efficacy.Results The total efficiency were 67.5% in control group and 86.0% in observation group.There was a significant difference between the two groups （ P 〈 0. 05 ）. The scorce of HAMD were de- creased after 2, 4 and 6 weeks in both groups. There was a significant difference between them （ P 〈 0.01 ）. The scores in observation group were lower than those in control group（P 〈0.01 ）. There was no significant difference on IL-6 in both groups before treatment, but had a significant difference after treat- ment（P 〈 0. 01 ）. Conclusions Escitalopram combined with sulpiride can be a variety of ways to im- prove the condition of patients with depression.

关 键 词：抑郁症 艾司西酞普兰 舒必利 白细胞介素-6 

分 类 号：R749.4[医药卫生—神经病学与精神病学]