^11C-胆碱和18F-FDGPET／CT显像在脑胶质瘤诊断中的应用  

Application of UC-choline and lSF-FDG PET/CT in diagnosing brain glioma

作　　者：展凤麟[1] 汪世存[1] 潘博[1] 倪明[1] 谢吉奎[1] 谢强[1] 钱立庭[2] 

机构地区：[1]安徽医科大学附属安徽省立医院PET/CT中心,合肥230001 [2]安徽医科大学附属安徽省立医院放疗科,合肥230001

出　　处：《国际放射医学核医学杂志》2013年第4期193-195,共3页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：安徽省科技攻关计划项目（0701302202）

摘　　要：目的探讨^11C-胆碱和^18F-FDGPET／CT在脑胶质瘤显像中的意义，以提高PET／CT对脑胶质瘤病变的诊断价值。方法分别对21例颅脑占位疑似脑胶质瘤患者行^11C-胆碱及^18F—FDGPET／CT颅脑显像，分析^11C-胆碱和^18F-FDG最大标准化摄取值（SUVmax）与患者年龄、病理类型之间的关系。结果21例患者的^18F-FDG和^11C-胆碱SUVmax与患者年龄无显著相关性，^18F-FDG SUVmax与病变的良、恶性也无显著相关性，而^11C-胆碱SUVmax与病变良、恶性存在一定相关性。结论^11C-胆碱PET／CT在诊断和鉴别颅内胶质瘤病变中具有重要的价值和意义。Objective To study the value of PET/CT using ^11C-choline and that of PET/CT using lSF-FDG for the diagnosis of brain glioma. Methods Twenty-one cases of suspected brain glioma were examined. ^11C-choline PET/CT and ISF-FDGPET/CT were performed on each patient to analyze the relevance of maximum standardized uptake value （SUVmax） of ^11C-choline and ^18F-FDG to the age and pathological types of patients with glioma. Results Of 21 patients, there was no significant correlation between SUVmax of ^11C-choline and ^18SF-FDG and their age, and between SUVmax of ^18F-FDG and benign and malignant tumors among patients, whereas there was certain correlation between SUVmax of ^11CC-choline and benign and malignant tumors among patients. Conclusion ^11CC-choline PET/CT is of great clinical value in diagnosing and differentiating brain glioma.

关 键 词：神经胶质瘤 碳放射性同位素 胆碱 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术 X线计算机 

分 类 号：R730.44[医药卫生—肿瘤]