Toll样受体4与肿瘤及其放射敏感性的研究进展  

Advance in toll-like receptor 4 and tumor and its radiosensitivity

作　　者：戚瑞祥[1] 董娟聪[1] 卢良杰[2] 张海芹[1] 金顺子[1] 

机构地区：[1]吉林大学公共卫生学院卫生部放射生物学重点实验室,长春130021 [2]宁波市医疗中心李惠利医院骨科,315040

出　　处：《国际放射医学核医学杂志》2013年第4期225-229,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（30870584）;教育部高等学校博士学科点专项科研基金（20120061110063）

摘　　要：Toll样受体4（TLR4）是一类重要的模式识别受体，不但广泛表达于免疫细胞，也表达于各种肿瘤细胞。TLR4通过不同的信号转导机制促进肿瘤的发生、发展、免疫逃逸、凋亡抵抗、转移和侵袭。激活的TLR4在肿瘤微环境中起着重要作用，且高表达的TLR4影响着肿瘤细胞的放射敏感性，进而严重影响肿瘤放疗的效果，对这些机制的研究可以进一步明确放疗的作用靶点，为恶性肿瘤的治疗提供新的手段。Toll-like receptor 4 （TLR4） is an important group of pattern recognition receptors, which is expressed not only on immune cells widely, but also on a variety of tumor cells. TLR4 can promote the development and progression, immune escape, apoptosis resistance, metastasis and invasion of tumors through different signal transduction mechanisms. Activated TLR4 plays an important role in the tumor microenvironment, and its influence on the radiosensitivity of tumor cells reduces the effect of radiation therapy severely. The study of these mechanisms can further identify the target for cancer radiotherapy, which will undoubtedly provide a new method for the treatment of malignant tumor.

关 键 词：TOLL样受体4 肿瘤 辐射耐受性 免疫逃逸 

分 类 号：R730[医药卫生—肿瘤]