乳腺癌中ErbB2过表达与血管内皮生长因子A,C和D高表达的关系  

ErbB2 Overexpression Correlates with Increased Expression of Vascular Endothelial Growth Factors A,C,and D in Human Breast Carcinoma

作　　者：李建国[1] 邢桂滨[1] 宋海彬[1] 常得丰[1] 

机构地区：[1]黑龙江省医院普外科,黑龙江哈尔滨150086

出　　处：《中国伤残医学》2013年第7期36-37,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨在乳腺癌中ErbB2过表达与血管内皮生长因子A,C和D的高表达关系。方法:用免疫组织化学方法检测107例乳腺癌患者和22例良性肿瘤中ErbB2、VEGF-A、VEGF-C和VEGF-D的表达。结果:VEGF-C和VEGF-D在乳腺癌的表达率高于乳腺的良性肿瘤,然而,VEGF-A、VEGF-C和VEGF-D的表达与erbB2的表达呈显著正相关,VEGF-A高表达而生存率降低,乳腺癌患者中VEGF-C或者VEGF—D高表达时,生存率更低,但是没有统计学意义,然而VEGF-A和VEGF—C联合表达水平比单一表达更有统计学意义。结论:血管与淋巴管的表达与ErbB2有一定的关系,VEGF-A和VEGFC的同时表达对患者预后生存率更有价值。Objective： ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma~ Methods：The expression levels of VEGF -A, VEGF- C, and VEGF- D protein in 107 breast carcinoma cases and 22 nonmalignant breast tissue samples were examined by immunohistochemistry Results ： Higher expression of VEGF - C and VEGF - D was found in breast carcinomas than in nonmalignant breast tissue samples. Moreover, expression of VEGF - A, VEGF - C, and VEGF - D was significantly and positively correlated with ErbB2 expression. High levels of VEGF - A expression were associated with shorter disease - free survival（DFS）. Patients with tumors expressing, high levels of VEGF - C or VEGF - D showed a notable trend for worse DFS, however, it was not statlsticallysignifieant. The combination of VEGF - A and VEGF - C status predicted survival better than either marker- alone. Conclusion ： Our study suggests that expression of the angiogenic and lymphangiogenic factors （ i. e. , VEGFs） might be regulated at least in part by ErbB2. In addition, the combination of VEGF - A andVEGF - C status may better predict prognosis Of patients with breast carcinoma than VEGF - A alone.

关 键 词：乳腺癌 VEGF—A VEGF—C VEGF—D ERBB2 

分 类 号：R737.9[医药卫生—肿瘤]