周剂量多西紫杉醇联合希罗达治疗晚期胃癌的临床观察  

Clinical study of weekly doxetaxel combining with xeloda treatment in patients with advanced gastric carcinoma

作　　者：凌华晃[1] 李涛[1] 钟亮[1] 曾湖[1] 蔡茂德[1] 

机构地区：[1]广东省高州市人民医院(广东医学院附属高州医院)化疗科,广东高州525200

出　　处：《中国现代医生》2013年第22期153-155,共3页China Modern Doctor

摘　　要：目的观察周剂量多西紫杉醇联合希罗达治疗晚期胃癌的临床疗效和安全性。方法将93例晚期胃癌患者随机分组,观察组48例,采用周剂量多西紫杉醇联合希罗达化疗方案:多西紫杉醇35 mg/m2静脉滴注第1天、第8天,希罗达2 500 mg/m2,分2次口服,第1天至第14天;对照组45例采用奥沙利铂(L-OHP)联合希罗达治疗。结果观察组CR 4例,PR 23例,SD 15例,PD 6例,有效率为56.3%;对照组CR 4例,PR 21例,SD 14例,PD 6例,有效率为53.5%,差异无统计学意义(χ2=0.0013,P=0.9714)。观察组中位TTP 6.5个月;对照组为5.2个月,差异有显著性(χ2=4.1655,P=0.0413)。两组不良反应主要表现为骨髓抑制和胃肠道反应,差异无统计学意义(P>0.05);观察组外周神经毒性较轻,差异有统计学意义(χ2=4.4524,P=0.0349)。KPS评分增高率分别为54.2%和22.2%,差异有统计学意义(χ2=4.5072,P=0.0338)。结论周剂量多西紫杉醇联合希罗达治疗晚期胃癌疗效较好,不良反应可以耐受,而在外周神经毒性、中位无进展时间及生存质量上优于对照组。Objective To observe the efficacy and toxicity of weekly doxetaxel combining with xeloda treatment inpatients with advanced gastric carcinoma. Methods Ninety-three patients with advanced gastric carcinoma were randomly allocated into two groups ： Forty-eight Patients in the study group were received weekly doxetaxel combiningwith xeloda chemotherapy treatment ： Intravenous infusions of docetaxel of 35 mg/m2 from dayl to day8, and xelodaof 2500mg/m2 for 14 days, 21 days for a cycle .Forty-three patients in the control group were received L-OHP combining with xeloda chemotherapy treatment. Results The patients in the study group were 4 cases received complete response ,23 cases received partial response, 15 cases received stable disease, 6 cases received progressive disease. Theoverall response rate was 56.3%. The patients in the control group were 4 cases received complete response, 21 casesreceived partial response, 14 cases received stable disease, 6 cases received progressive disease. The overall responserate was 53.5%. The overall response rates in the two groups were similar （χ2=0.0013 ,P = 0.9714）. The middle timeto progress in the two groups were respectively 6.5 months and 5.2 months,they were statistically significant difference（χ2=4.1655 ,P = 0.0413）. The toxicities of myelosuppression and gastrointestinal were main in the two groups,Theywere similar （P 〉 0.05）. The toxicities of peripheral neuritis were smaller in the study group, they were statisticallysignificant difference （χ2=4.4524,P = 0.0349）.The improvement rates of Kamofsky performance status score in the twogroups were respectively 54.2% and 22.2%,they were statistically significant difference（χ2=4.5072 ,P = 0.0338）.Conclusion Weekly doxetaxel combining with xeloda treatment should be considered safe and effective chemotherapyregimens in patients with advanced gastric carcinoma. It seemed superiority in the toxicities of peripheral neuritis andthe time to progress and the quality of life.

关 键 词：多西紫杉醇 希罗达 奥沙利铂 晚期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]