结肠癌组织中Bmi-1表达变化及意义  

Expression and significance of Bmi-1 in human colon carcinoma

作　　者：张念华[1,2,3] 宋立兵[1,2] 丁娅[1,2] 彭瑞清[1,2] 曾木圣[1,2] 张晓实[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广州510060 [2]中山大学肿瘤防治中心 [3]广东省第二中医院

出　　处：《山东医药》2013年第26期30-33,共4页Shandong Medical Journal

摘　　要：目的观察结肠癌组织中Bmi-1的表达变化,探讨其临床意义。方法采用免疫组化法检测64例接受根治性手术治疗的结肠癌患者结肠癌组织标本、瘤旁结肠上皮组织及淋巴结转移灶中的Bmi-1,并以5例结肠息肉标本为对照。分析患者临床病理资料与Bmi-1表达的相关性。结果 64例结肠癌标本中Bmi-1蛋白阳性表达率为62.5%(40/64),64例瘤旁结肠上皮组织中Bmi-1蛋白阳性表达率为12.5%(8/64)。与瘤旁结肠上皮组织相比,结肠癌标本中Bmi-1蛋白阳性表达率显著升高(P<0.05)。在结肠息肉组织中未见Bmi-1蛋白阳性表达。不同Dukes分期及病理分级的患者Bmi-1蛋白阳性表达率相比,P均<0.05。结论 Bmi-1蛋白在结肠癌组织中呈高表达,可能与肿瘤的进展有关。Objective To examine whether over expression of Bmi-1 is associated with colon carcinoma characteristics,we evaluated Bmi-1 expression in colon tissue and in primary and lymphonode metastatic tissues of different Dukes stages colon carcinoma.Methods Immunohistochemical staining for Bmi-1 was carried out on paraffin-embedded tissues from 64 colon carcinoma patients who had undergone radical surgery.The correlation of Bmi-1 expression to clinicopathologic features of colon carcinoma was analyzed.Results The intensive positive rate of Bmi-1 in colon carcinoma was 62.5%（40 /64）,which was 12.5%（8 /64） in the colon tissue beside tumor tissue.Compare with the colon tissue beside tumor tissue,Bmi-1 over expression is common in colon carcinoma（P〈0.05）.There was no Bmi-1 expression in colonic polyp tissues.The intensive expression of Bmi-1 was positively correlated to Ducks stage and pathologic grade（P〈0.05）.Conclusions The intensive expression of Bmi-1 in colon carcinoma is related to tumor progression.

关 键 词：结肠癌 多梳基因 免疫组化 

分 类 号：R735.3[医药卫生—肿瘤]