妊娠期卵巢非特异性类固醇细胞瘤临床病理观察  

Ovarian steroid cell tumor,not otherwise specified during pregnancy:a clinical pathologic review

作　　者：徐基成[1,2] 雷龙春[3,4] 余绍兰[1,2] 王青青[1,2] 李晓琼[1,2] 

机构地区：[1]四川省妇幼保健院 [2]四川省妇女儿童医院病理科,四川成都610045 [3]四川省医学科学院 [4]四川省人民医院城东病区病理科,四川成都610101

出　　处：《四川医学》2013年第6期784-786,共3页Sichuan Medical Journal

摘　　要：目的控讨非特异性类固醇细胞瘤的临床病理特征、诊断和鉴别诊断要点。方法观察1例妊娠期非特异性类固醇细胞瘤HE及免疫组化特点,并复习文献。结果肿瘤呈囊实性,囊性部分为良性畸胎瘤,与实性部分有纤维包膜分隔。实性部分瘤细胞形态大致分为两种,一种为嗜酸性颗粒状胞浆的细胞,另一种为胞质透明的细胞。免疫组织化学显示:肿瘤细胞calretinin、a-inhibin、Melan-A、CD99阳性表达。结论非特异性类固醇细胞瘤是类固醇细胞中最常见的类型,良性多见。而妊娠期非特异性类固醇细胞瘤非常罕见。免疫组织化学有助于诊断和鉴别诊断。Objective To study the clinical pathological characteristics and criterions for diagnosis,differential diagnosis for the steroid cell tumuor,otherwise not specified（NOS） of ovary.Methods The characteristic of hematoxylin-eosin（HE） staining sections and immunohistochemistry examination of one case with NOS during pregnancy were studied and the related literatures were reviewed.Results The tumor was organized with cystic form and parenchymatous form.The cystic form was benign teratoma and was separated from parenchymatous form with fibros caps.The neoplasm mainly had two types of cell,one type was polygonal cell with cytoplasm that was usually granular and eosinofilic,and the other type was cells with valculated cytoplasm.These neoplasmous cells were usually immunoreactive to alpha-inhibin,calretinin,Malan-A,CD99.Conclusion NOS of ovarian steroid cell tumors,most of which are associated with benign clinical outcome,is the most common type of ovarian steroid cell tumors.While ovarian steroid cell tumors,NOS during pregnancy is very rare.Immunohistochemistry is an important adjunct for diagnosis and differential diagnosis.

关 键 词：妊娠期 非特异性类固醇细胞瘤 病理特征 

分 类 号：R737.31[医药卫生—肿瘤]