肝硬化腹水患者血清与腹水中LDH、ADA、SAAG联合检测的临床意义  

Clinical sigficance of combined detection of LDH, ADA and SAAG in serum and ascites in patients with cirrhosis ascites

作　　者：王建芳[1] 郁金红[1] 赵磊[1] 王志龙[1] 

机构地区：[1]东南大学附属第二医院肝病研究室,江苏南京210003

出　　处：《检验医学与临床》2013年第A01期45-47,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨联合检测肝硬化腹水患者腹水／血清LDH、ADA、SAAG的临床意义。方法以117例肝硬化腹水患者为研究对象，设立两组对照：肝癌腹水组36例，结核性腹膜炎组26例，分别对3组腹水中的LDH、ADA、SAAG及其对应血清中的LDH、ADA、SAAG进行测定，对其结果比较分析。结果肝硬化腹水组SAAG与肝癌腹水组的SAAG比较差异无统计学意义（P〉0．05）；肝硬化腹水组SAAG与结核性腹膜炎组sAAG比较，以及肝癌性腹水SAAG与结核性腹膜炎组sAAG比较差异均有统计学意义（P〈0．05）。肝硬化腹水组LDH、肝癌腹水组LDH与结核性腹膜炎组三组中两两比较差异均有统计学意义（P〈O．05）。肝硬化腹水组ADA与肝癌腹水组ADA比较差异无统计学意义（P〉0．05）；肝硬化腹水组ADA与结核性腹膜炎组ADA比较以及肝癌腹水组ADA与结核性腹膜炎组ADA比较差异均有统计学意义（P〈0．05）。结论腹水中的LDH、ADA、sAAG及其对应血清中LDH、ADA、sAAG指标联合检测并计算其比值，对临床肝硬化腹水诊断有一定的实用价值，值得推广。Objective To investigate clinical significance of combined detection of serum and ascites lactate dehydrogenase （LDH）, adenosine deaminase （ADA） and serum--ascites albumin gradient （SAAG） in patients with cirrhosis ascites. Methods Serum and ascites LDH, ADA and SAAG were detected in 177 patients with cirrhosis as- cites, 36 cases with hepatocarcinoma aseites and 26 cases with tuberculous peritonitis, and the results were com- pared. Results There was no statistical difference in SAAG concentration between group of cirrhosis ascites and hep atocarcinoma ascites（P〈0.05）, but with statistical difference between cirrhosis ascites and tuberculous peritonitis groups and hepatocarcinoma ascites and tuberculous peritonitis groups （P〈0.05）. There was statistical difference of LDH in patients with cirrhosis ascites and tuberculous peritonitis and hepatocarcinoma ascites （P〈0.05）. There was no statistical difference of serum and ascites ADA in patients with cirrhosis ascites and hepatocarcinoma aseites （P^0.05）. There was statistical difference of serum and ascites ADA in patients with cirrhosis ascites and tubercu- lous peritonitis, and hepatocarcinoma ascites and tuberculous peritonitis （P〈0.05）. Conclusion Combined detection of serum and aseites LDH, ADA and SAAG and calculation of its rate could have practical value in diagnosis of cirrhosis ascites, and might serve as a complementarity in diagnosis of portal hypertension.

关 键 词：肝硬化腹水 血清 腺苷脱氨酶 乳酸脱氢酶 血清-腹水清蛋白梯度 

分 类 号：R575.2[医药卫生—消化系统]