多功能蛋白聚糖与肿瘤发生发展关系的研究进展  

Progress of versican in the occurrence and development of neoplasms

作　　者：冯和林[1] 赵亚恒[1] 郑丽华[2] 冯建刚[1] 

机构地区：[1]河北医科大学第四医院骨科,石家庄050011 [2]河北医科大学第四医院乳腺外科,石家庄050011

出　　处：《国际外科学杂志》2013年第7期485-488,共4页International Journal of Surgery

基　　金：河北省科技厅支撑课题（No.11276156）

摘　　要：多功能蛋白聚糖来自成纤维细胞，属于软骨素蛋白聚糖，分布在多种组织中。多功能蛋白聚糖具有调节细胞生长、分化，促进细胞增生、侵袭、转移，促进血管发生的功能。实验证实多功能蛋白聚糖的表达参与多种肿瘤的发生、发展。本文就多功能蛋白聚糖与乳腺癌、肝癌以及软骨肉瘤的发生、发展关系作一综述，以进一步探求肿瘤的发病机制。Versican comes from fibroblasts and belongs to chondroitin sulfate proteoglycan. It distributes in vari-ous tissues. The versiean have functions including regulate cell growth and differentiation, promote cell prolifera-tion, invasion and metastasis, and stimulate angiogenesis. Experiments have confirmed that the expression of versi-can is involved in various cancers. Here, the author do an overview of versican in the occurrence and development of breast cancer, liver cancer and chondrosarcoma aimed to further explore the pathogenesis of tumors.

关 键 词：多功能蛋白聚糖 肿瘤 乳腺肿瘤 肝肿瘤 软骨肉瘤 

分 类 号：R575.3[医药卫生—消化系统]