联合检测CA199、CA242、CEA对胰腺癌诊断价值的Meta分析  

Combined Detection of CA199,CA242 and CEA in the Diagnosis for Pancreatic Cancer: A Meta Analysis

作　　者：颜海希[1] 郑静[1] 金霞霞[1] 沈波[1] 

机构地区：[1]台州医院,浙江临海317000

出　　处：《肿瘤学杂志》2013年第7期532-538,共7页Journal of Chinese Oncology

摘　　要：[目的]评价联合检测血清CA199、CA242、CEA在胰腺癌诊断中的价值。[方法]采用计算机全面收集当前联合检测CA199、CA242、CEA对胰腺癌诊断性试验的文献。采用Meta-Disc14.0、Stata10.0进行Meta分析。[结果]共纳入符合文献11篇。在合并分析中,化学发光法联合检测的灵敏度(SE)、特异性(SP)、SROC曲线下面积(AUC)分别为0.90(0.85～0.93)、0.78(0.75～0.83)、0.9513。单独检测CA199的SE、SP、AUC分别为0.80(0.75～0.84)、0.81(0.76～0.85)、0.8824。联合和单独两种检测方式的诊断效能比较差异有统计学意义(Z=2.999,P=0.0027)。蛋白芯片法联合检测的SE、SP、AUC分别为0.84(0.80～0.88)、0.87(0.82～0.91)、0.9293。单独检测CA199的SE、SP、AUC分别为0.78(0.73～0.82)、0.86(0.81～0.90)、0.8823。联合和单独两种检测方式的诊断效能比较差异无统计学意义(Z=1.141,P=0.157)。[结论]在胰腺癌的临床辅助诊断中,与单独检测CA199比较,联合检测的判别能力较强,可提高诊断效能。[Purpose] To investigate the value of combined detection of the tumor markers CA199,CA242 and CEA in the diagnosis for pancreatic cancer.[Methods] A computerized literature search was carried out in the databases to collect articles regarding the diagnostic value of combined detection of the cancer markers CA199,CA242 and CEA. Meta-Disc14.0 and Stata10.0 software were used to conduct the meta-analysis.[Results] A total of 11 literatures were obtained in the present study with the unified inclusion and exclusion criteria. By chemiluminescence immunoassay,the results showed that the sensitivity （SE）,specificity （SP）,area under curve of SROC curve（AUC） of the tumor markers CA242,CA199 and CEA were 0.90（0.85~0.93）, 0.78（0.75~0.83）,0.9513 respectively in the diagnosis for pancreatic cancer. In contrast,the indices of SE,SP,AUC of the marker CA199 that was detected alone were 0.80（0.75~0.84）,0.81 （0.76~ 0.85）,0.8824 respectively. The result of the Z test has proven that significant difference between the two methods（Z=2.999,P=0.0027）.By protein chip system for multi-tumor markers detection, the indices of SE,SP,AUC of the tumor markers CA242,CA199 and CEA were 0.84 （0.80 ～ 0.88）,0.87 （0.82～0.91）,0.9293,respectively.In contrast,the indices of SE,SP and AUC of the marker CA199 that was detected alone were 0.78（0.73～0.82）,0.86（0.81～0.90）,0.8823 respectively. The result of the Z test has proven no significant difference between the two methods （Z= 1.414,P=0.157）. [Conclusion]The combined detection of CA199,CA242 and CEA in the clinically auxiliary diagnosis for pancreatic cancer may provide more competent and valuable laboratory proof compared with solitary detection of CA199.

关 键 词：糖类抗原199 糖类抗原242 胰腺肿瘤 META分析 

分 类 号：R735.9[医药卫生—肿瘤]