非典型脑膜瘤的临床病理特点及预后分析  

Clinicopathologic Features and Prognostic Analysis of Atypical Meningiomas

作　　者：余晶晶[1,2] 梁伟[1,2] 周军[1,2] 张新华[1,2] 余波[1,2] 章如松[1,2] 周晓军[1,2] 

机构地区：[1]南京大学医学院临床学院 [2]南京军区南京总医院,江苏南京210002

出　　处：《肿瘤学杂志》2013年第7期553-557,共5页Journal of Chinese Oncology

摘　　要：[目的]探讨非典型脑膜瘤(AM)的临床病理学特点及预后相关因素。[方法]回顾性分析54例AM的临床病理资料,并根据随访结果将患者分成死亡复发组和无死亡复发组,对两组患者的8项临床病理学指标进行统计分析。[结果]54例AM患者中位年龄58岁,次全切除8例。30例肿瘤最大径≥5cm,17例见肿瘤侵犯脑组织,13例核分裂≥4/10HPF,32例可见肿瘤组织自发性坏死,26例肿瘤细胞有明显核仁,Ki-67指数平均为7.04%。36例无复发存活,7例复发,11例死亡。上述8项指标在两组之间的差异均具有统计学意义(P<0.05)。[结论]肿瘤最大径≥5cm、未被完全切除、肿瘤侵犯脑组织、有自发性坏死、瘤细胞有显著核仁、核分裂≥4/10HPF、Ki-67指数≥7%是非典型脑膜瘤患者复发或死亡的危险因素。[Purpose] To investigate the clinicopathologic characteristics of atypical meningioma （AM） and the relevant prognostic factors. [Methods] Clinicopathologic data of 54 cases with AM were retrospectively reviewed. On the basis of follow-up data,patients were divided into two groups：recurrence or death group and recurrence -free survival group. Eight clinicopathologic parameters related to recurrence or death were evaluated in each patient. [Results] Of the 54 cases,median age was 58 years old,8 cases were subtotal resection. The maximum diameter of 30 cases were ≥5cm. Brain invasion occurred in 17 cases. There were 13 cases with mitotic figures ≥4/10HPF,32 cases with spontaneous necrosis,26 cases with distinct nucleoli,and the mean index of Ki-67 was 7.04%. Thirty-six cases were recurrence-free survival;7 cases,recurred; and 11 cases,died. There were 8 clinicopathologic parameters with significant difference between the two groups（P0.05）. [Conclusion] Tumor size ≥5cm in diameter,subtotal resection, brain invasion,spontaneous necrosis,distinct nucleolus,more than 4/10HPF in mitotic figures and 7% in Ki-67 index are the risk factors related to recurrence or death in the patients with AM.

关 键 词：非典型脑膜瘤 临床病理学 预后 

分 类 号：R739.45[医药卫生—肿瘤]