失重状态造成肌萎缩的研究与进展  

Weightlessness causes lower limb muscle atrophy

作　　者：韩忠宇[1] 贾懿劼[1] 田京[2] 

机构地区：[1]南方医科大学珠江医院 [2]南方医科大学珠江医院骨科中心,广东省广州市510282

出　　处：《中国组织工程研究》2013年第28期5249-5254,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:失重是导致宇航员下肢肌萎缩的重要原因之一,严重危害宇航员身体健康。目的:探讨失重状态造成肌萎缩的发生机制。方法:由第一作者分别应用计算机检索PubMed英文数据库和中国期刊全文数据库中1997年5月至2013年3月的文献。在标题、摘要和关键词中以"weightless,weightlessness,muscle,atrophy,space,失重,骨骼肌,萎缩,太空"为检索词进行检索。选择文章内容与失重状态造成肌萎缩研究机制相关者,同一领域则选择最新研究进展者。结果与讨论:初选得到文献409篇,根据纳入标准选择47篇文献进行综述。失重状态造成肌萎缩的发生机制是目前宇航医学的研究热点。目前造成失重性肌萎缩主要原因主要包括外周感觉神经所获取信息传导减少导致肌梭神经营养因子合成减少、肌细胞超微结构破坏:线粒体肌原纤维大幅下降、肌钙合成蛋白质减少、肌细胞内钙含量减少,下肢抗重力肌群血流量减少等多方面。METHODS： A computer-based online search of PubMed database and CNKI database was performed to search related articles between May 1981 and March 2013 with the key words of ＂weightless, weightlessness, muscle, atrophy, space＂ in English and Chinese, respectively. Literatures related to progress of weightlessness that cause lower limb muscle atrophy were selected; in the same field, the literatures published lately in authoritative journals were preferred. RESULTS AND CONCLUSION： A total of 409 literatures were primarily selected, and 47 documents were involved for summary according to the inclusion criteria. The progress of weightlessness that cause muscle atrophy is the hot topic among the space medical research. The main reasons that cause weightlessness muscular atrophy include the reduced muscle spindle neurotrophic factor synthesis caused by reduced information transmission of peripheral sensory nerve, damage of muscle cell ultrastructure, substantial decline in mitochondrial myofibrils, troponin decreasing, decreased intracellular calcium content, and decreased antigravity muscle blood flow in lower limbs.

关 键 词：组织构建 组织构建综述 肌肉肌腱韧带组织构建 失重 肌萎缩 航天 超微结构 蛋白质 信息传导 

分 类 号：R318[医药卫生—生物医学工程]