PDT联合血栓通治疗AMD并发脉络膜新生血管化  

Photodynamic therapy combined with the Sanqi Panax Notoginseng for patients with age-related macular degeneration and choroidal neovascularization

作　　者：宋玫侠[1] 李上[1] 王丽 孙丰[1] 蒋永强[1] 李红[1] 

机构地区：[1]解放军第153中心医院东区眼科,中国河南省郑州市450007 [2]空军西安建国公园干休所,中国陕西省西安市710002

出　　处：《国际眼科杂志》2013年第8期1628-1630,共3页International Eye Science

摘　　要：目的: 观察光动力疗法(PDT)联合中药血栓通注射液治疗年龄相关性黄斑变性(AMD)并发脉络膜新生血管化(CNV)的临床疗效。方法: 选择年龄相关性黄斑变性并发脉络膜新生血管化(AMD-CNV)患者17例17眼,男7例,女10例,年龄53～72岁。患者经过视力、眼压、荧光素眼底血管造影(FFA)、吲哚青绿血管造影(ICGA)和光学相干断层成像(OCT)等检查确诊。患者用PDT治疗5d后,再用500mg中药血栓通注射液静脉滴注10d,1次/d,疗程为15d,观察治疗后1,3和6mo疗效。结果: 治疗6mo,17例中视力提高8例(47%),视力稳定无明显变化6例(35%),视力下降3例(18%);12例(71%)CNV闭合且渗漏完全停止,5例(29%)CNV大部分闭合。1例出现一过性视物模糊。结论: PDT联合中药血栓通注射液治疗AMD-CNV方法简单,疗效可靠,可在临床推广应用。·AIM： To investigate the clinical effect of photodynamic therapy （PDT） combined with Traditional Chinese medicine Sanqi Panax Notoginseng therapy for age- related macular degeneration （AMD） and choroidal neovascularization （CNV）. ·METHODS： Seventeen patients （17 eyes） with AMD and CNV were diagnosed by visual acuity, ocular pressure, fundus fluorescein angiography （ FFA）, idocyanine green angiography （ ICGA ） and optic coherence tomography （OCT）, and male 7 cases, female 10 cases, age 53- 72 years old. PDT was performed using the recommended standard procedure. The patients were treated with PDT for 5 days, and Sanqi Panax Notoginseng 500mg injection by intravenous drip for 10 days, once a day, 15 days as one course. One month, 3, 6 months of follow-up after treatment.·RESULTS： Of 17 patients after 6 months treatment, visual acuity improved in 8 cases （47%, 8/17）, remained stable in 6 cases （35%）, and decreased in 3 cases （18%）; and 12 cases （71%1） with CNV closure and leakage stopped completely, 5 cases （29%） with most of the CNV＇s closure, 1 patient experienced blurred vision. ·CONCLUSION： The results show that PDT combined with traditional Chinese medicine Sanqi PanaxNotoginseng in treatment of ADM-CNV is simple and has reliable effect, it can be used in clinical application.

关 键 词：光动力疗法 血栓通 年龄相关性黄斑变性 脉络膜新生血管化 

分 类 号：R774.5[医药卫生—眼科]