宫颈癌组织中凋亡因子表达的分析  

Expression of apoptotic factors in the tissues of cervical cancer

作　　者：周晓宁[1] 张宏斌[2] 张伟[3] 陈晓东[3] 

机构地区：[1]广州军区广州总医院妇产科,广东广州510010 [2]广州军区广州总医院医学实验科,广东广州510010 [3]广州军区广州总医院病理科,广东广州510010

出　　处：《西北国防医学杂志》2013年第4期316-318,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨凋亡因子表达水平与宫颈癌发生、发展过程的关系。方法:免疫组化法检测宫颈癌组织标本中NF-κB、Caspase-3及Bcl-2表达。结果:NF-κB及Caspase-3在宫颈浸润性鳞细胞癌中表达阳性率较宫颈原位鳞细胞癌显著降低(P<0.01),且二者表达呈对应关系;Bcl-2的表达均为阴性。结论:NF-κB与Caspase-3相互拮抗调节宫颈鳞细胞癌的发展,这种调控的变化可能与肿瘤的恶性转化相关,调控NF-κB与Caspase-3的拮抗表达值得作为宫颈鳞细胞癌治疗的一个新研究方向。Bcl-2表达阴性提示在宫颈鳞细胞癌发生、发展中,线粒体凋亡通路可能缺失。Objective：To investigate the relationship between the expression level of apoptotic factors and the occurrence and development of cervical cancer.Methods： Immunohistochemical stain was used to detect the expression of NFκ-B,Caspase-3 and Bcl-2 in tissue samples from the patients with cervical squamous cell cancer.Results： The positive rates of expressions of NFκ-B and Caspase-3 were significantly reduced in the tissues of invasive cervical squamous cell carcinoma than that of in situ cervical squamous cell carcinoma,and their expression were corresponding（P0.01）.No expression of Bcl-2 was found.Conclusion： The antagonism between Caspase-3 and NFκ-B regulates the development of cervical squamous cell carcinoma,and the changes of Caspase-3 and NFκ-B expression level are related with malignant transformation.The antagonistic regulation of Caspase-3 and NFκ-B is a new research direction in cervical squamous cell carcinoma.The negative expression of Bcl-2 implied that mitochondrial apoptotic pathway may be lost in the development of cervical squamous cell carcinoma.

关 键 词：宫颈癌 凋亡因子 检测 

分 类 号：R737.33[医药卫生—肿瘤]