MOC-31在鉴别良恶性浆膜腔积液中诊断价值的Meta分析  

Diagnostic value of MOC-31 for benign and malignant effusion: a meta-analysis

作　　者：陈超[1] 黄勇[1] 成远[1] 张珏[1] 陈歆妮[1] 薛松[1] 陈映霞[1] 

机构地区：[1]解放军八一医院全军肿瘤中心肿瘤内科,南京210002

出　　处：《临床肿瘤学杂志》2013年第7期603-607,共5页Chinese Clinical Oncology

摘　　要：目的通过荟萃分析以确定MOC-31在鉴别良恶性浆膜腔积液中的诊断价值。方法检索国内外数据库,采用诊断性试验荟萃分析的标准方法对纳入文献进行系统评价,汇总各研究中MOC-31在鉴别良恶性浆膜腔积液的灵敏度、特异度、阳性似然比、阴性似然比及诊断优势比,并绘制总的受试者工作特征曲线(SROC)。结果最终纳入16项独立研究进行荟萃分析,共1602例样本。MOC-31诊断恶性浆膜腔积液的灵敏度为0.90(95%CI:0.88～0.92),特异度为0.98(95%CI:0.96～0.99),阳性似然比为18.43(95%CI:11.38～29.84),阴性似然比为0.11(95%CI:0.07～0.17),诊断优势比为349.19(95%CI:138.73～878.95)。灵敏度与特异度交点最大值为0.96。结论 MOC-31在鉴别良恶性浆膜腔积液中的灵敏度与特异度较高,SROC曲线显示其诊断效率较高,具有较广阔的临床应用前景。Objective To determine the accuracy of MOC-31 in the diagnosis of the malignant effusion by meta-analysis. Methods We search the databases of domestic and international. After a systematic review of both English and Chinese literatures, the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio accuracy of MOC-31 in the diagnosis of benign and malignant effusion were pooled using random effects models. Summary receiver operating characteristic curves was used to summarize overall test performance. Results Sixteen studies involving 1602 samples were included. The summary estimation for MOC-31 in the diagnosis of benign and malignant effusion was as follows. The sensitivity was 0. 90（95% CI：0. 88-0. 92）, specificity 0. 98 （ 95 % CI ： 0. 96-0. 99 ）, positive likelihood ratio 18.43 （ 95 % CI ： 11.38-29. 84 ）, negative likelihood ratio 0. 11 （ 95 % CI ： 0. 07- 0. 17） and diagnostic odds ratio 349. 19 （95% CI： 138.73-878.95 ）. The crossing point of sensitivity and specificity （Q value） was 0. 96. Conclusion MOC-31 determination is a high sensitive, specific and SROC test for the diagnosis of malignant effusion. Meas- urement of MOC-31 is thus likely to be a useful diagnostic tool for benign and malignant effusion. The results of MOC-31 assays should be interpreted in parallel with clinical findings and results of laboratory examination.

关 键 词：MOC-31 浆膜腔积液 良恶性 诊断 META分析 

分 类 号：R730.4[医药卫生—肿瘤]