SLC30A8基因多态性与肾移植后糖尿病的相关性  

Association between SLC30A8 gene polymorphisms and diabetes mellitus after renal transplantation

作　　者：余爱荣[1] 范星[2] 刘慧明[1] 辛华雯[1] 吴笑春[1] 

机构地区：[1]解放军广州军区武汉总医院,临床药理科,湖北省武汉市430070 [2]解放军广州军区武汉总医院,肾内科,湖北省武汉市430070

出　　处：《中国组织工程研究》2013年第31期5613-5619,共7页Chinese Journal of Tissue Engineering Research

基　　金：湖北省自然科学基金计划资助项目(2009CDB010)~~

摘　　要：背景:前期研究已经发现,2型糖尿病的易感基因脂联素基因、钙蛋白酶10基因等与中国肾移植患者移植后糖尿病的发生显著相关。猜测其他2型糖尿病的易感基因是否也与移植后糖尿病相关。目的:分析锌转运蛋白-8(SLC30A8)基因多态性与移植后糖尿病的相关性。方法:采用实时荧光定量PCR法检测97例移植后糖尿病患者和301例未发生移植后糖尿病的肾移植患者(对照组)的SLC30A8 rs13266634的基因型,采用logistic回归分析该基因多态性与移植后糖尿病的相关性。结果与结论:移植后糖尿病组和对照组患者rs13266634的等位基因频率和基因型分布差异具有显著性意义(P<0.05)。用性别、移植时年龄、体质量和体质量指数等危险因素进行校正后,CC基因型患者肾移植后发生移植后糖尿病的风险是TT基因型患者的2.108倍(OR=2.108,95%CI:1.075-4.131,P=0.044);CC+CT基因型患者肾移植后发生移植后糖尿病的风险是TT基因型患者的1.862倍(OR=1.862,95%CI:1.049-3.306,P=0.034)。提示SLC30A8基因rs13266634的C等位基因是肾移植后发生移植后糖尿病的独立危险因素。BACKGROUND： Previous studies have found that the susceptibility genes of adiponectin gene and calpain 10 gene of type 2 diabetes are closely related with the incidence of diabetes in Chinese renal transplantation patients. So, are other susceptibility genes of type 2 diabetes also associated with posttransplantation diabetes mellitus？ OBJECTIVE： To investigate the association between the zinc transporter solute carrier family 30 member 8 （SLC30A8） gene polymorphism and the posttransplantation diabetes mellitus. METHODS： A total of 97 patients with posttransplantation diabetes mellitus and 301 patents without posttransplantation diabetes mellitus （control group） were selected, and then the SLC30A8 gene rs13266634 genotype was detected with real-time PCR method. The association between gene polymorphism and posttransplantation diabetes mellitus was analyzed with Logistic regression test. RESULTS AND CONCLUSION： There were significant differences in allele frequencies and genotype distributions of rs13266634 between the patients with and without posttransplantation diabetes mellitus （P 0.05）. After adjustments of age, sex, body weight and body mass index, the incidence of posttransplantation diabetes mellitus of the CC genotype patients was 2.108 times to that of the TT genotype patients （odds ratio=2.108, 95% confidence interval： 1.075-4.131, P=0.044）; and the incidence of posttransplantation diabetes mellitus of the CC＋CT genotype patients was 1.862 times to that of the TT genotype patients （odds ratio=1.862, 95% confidence interval： 1.049-3.306, P=0.034）. The results suggest that the C-allele in rs13266634 of SLC30A8 gene is the independent risk factor of posttransplantation diabetes mellitus.

关 键 词：器官移植 肾移植 移植后糖尿病 SLC30A8基因 rs13266634 单核苷酸多态性 危险因素 等位基因 糖尿病 省级基金 

分 类 号：R318[医药卫生—生物医学工程]