颈动脉狭窄与进展性脑卒中的相关性  

Correlation of the Carotid Artery Stenosis and Stroke in Progression

作　　者：徐琴[1,2] 张微微[1] 魏微[1] 黄勇华[1] 王国强[1] 

机构地区：[1]北京军区总医院神经内科,北京市100700 [2]山西医科大学,山西省太原市030001

出　　处：《中国动脉硬化杂志》2013年第7期619-622,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81070948);国家自然科学基金项目(81171100)

摘　　要：目的研究颈动脉狭窄与进展性脑卒中的相关性,进一步探讨进展性脑卒中的危险因素。方法选取2012年2月～2012年12月在北京军区总医院神经内科住院经头颅核磁证实的急性缺血性脑卒中患者239例,按照病情是否加重(NIHSS评分)分成进展性脑卒中组(进展组)141例和非进展性脑卒中组(非进展组)98例,两组患者均行颈动脉超声检查,比较两组患者颈动脉狭窄程度与进展性脑卒中的相关性。结果在进展组内颈动脉狭窄的发生率明显高于非进展组。颈动脉狭窄与进展性脑卒中呈相关性,多因素Logistic回归分析显示,高脂血症、高同型半胱氨酸水平、颈动脉狭窄是进展性脑卒中发生的独立危险因素(OR=0.264,95%CI:0.064～1.260;OR=0.163,95%CI:0.036～0.743;OR=0.006,95%CI:0.036～0.568)。结论颈动脉狭窄程度与进展性脑卒中的发生密切相关,通过观察颈动脉狭窄的发生率可预测脑卒中的发生发展。Aim To observe the relationship between carotid artery stenosis and stroke in progression（SIP）, and further discuss the risk factors of SIP. Methods 239 hospitalized patients from the Beijing Military General Hospital with acute cerebral infarction were randomly allocated into two groups： stroke in progression（SIP） group（n141） and stable cerebral infarction group（n98）. Carotid ultrasonography examination was performed. The plasma Hcy were determined by radio-immunofluo rescence. The carotid artery stenosis degree and the plasma homocysteine levels of two groups were compared. Results The incidence of carotid artery stenosis in progress group was obviously higher than stable cerebral infarction group. The carotid artery stenosis is associated with stroke in progression. Logistic regression analysis show that hyperlipemia, homocysteine, carotid artery stenosis were the independent risk factors to stroke in progression（OR0.264,95%CI：0.064～1.260OR0.163,95%CI：0.036～0.743OR0.006,95%CI：0.036～0.568）. Conclusion Carotid artery stenosis may be closely related to ischemic stroke in progression, and the level of Hcy is a prediction of progressive cerebral infarction.

关 键 词：进展性脑卒中 高同型半胱氨酸血症 颈动脉狭窄 

分 类 号：R743[医药卫生—神经病学与精神病学]