D-二聚体水平与非霍奇金淋巴瘤患者预后关系的研究  

Relationship of D-dimer with the prognosis of non-Hodgkin's lymphoma

作　　者：姜文华[1] 高军[2] 刘鹏飞[3] 

机构地区：[1]天津医科大学第二医院放疗科,天津市300211 [2]河北省衡水哈励逊国际和平医院肿瘤内科 [3]天津医科大学附属肿瘤医院淋巴瘤内科

出　　处：《中国肿瘤临床》2013年第14期838-841,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:本研究拟探讨D-二聚体升高与非霍奇金淋巴瘤(Non-Hodgkin Lymphoma NHL)患者总生存之间的关系。方法:回顾性分析2000年1月至2009年12月天津医科大学附属肿瘤医院收治的经病理证实的NHL 425例,分析患者临床病理特征、D-二聚体及国际预后指数(the International prognostic index,IPI)对总生存的影响。结果:血浆D-二聚体水平与IPI评分明显相关。低、中、高水平D-二聚体组5年生存率分别为97.4%,86.1%,35.0%(P<0.05)。与IPI为0或1的患者相比,IPI≥4分者预后较差(P<0.05)。Ann Arbor分期、病理类型、D-二聚体水平以及IPI评分是影响总生存的主要因素,多元分析表明IPI评分、血浆D-二聚体水平是独立预后因子。结论:高水平的D-二聚体是NHL患者预后差的标志物。Objective： Increased D-dimer level has been recently correlated with the progression and high mortality rate of some cancers. This study aimed to determine whether the plasma D-dimer level was a predictor of non-Hodgkin lymphoma （NHL）. Methods： Clinical data of 425 with NHL were retrospectively reviewed. Variables such as clinieopathological factors, plasma D-dimer levels, and the international prognostic index （IPI） were evaluated. Results： The plasma D-dimer level was closely correlated with the IPI. The overall 1-, 3-, and 5-year survivai rates of the low plasma D-dimer levels were 80%, 75%, and 50%; those for the high plasma D-dimer levels were 41%, 33%, and 9%, respectively （P〈0.001）. Compared with an IPI of zero or one, IPI values ≥4 were predictive of poor prognosis （P〈0.001）. The Ann Arbor stage, pathological classification, plasma D-dimer level, and IPI were found to be significantly as- sociated with mortality. However, similar to IPI, the plasma D-dimer level was the independent risk factor affecting multivariate analy- sis. Conclusion： High D-direct levels are a potential prognostic marker for NHL.

关 键 词：D-二聚体 非霍奇金淋巴瘤 预后 

分 类 号：R733.1[医药卫生—肿瘤]