调节性T淋巴细胞在结肠癌组织中不同部位的浸润及其临床意义  

Inf＇dtration of regulatory T lymphocyte into different parts of colon carcinoma and clinical implica- tion

作　　者：徐为[1] 付海啸[1] 邱磊[1] 宋军[1] 张宝福 郑骏年 

机构地区：[1]徐州医学院附属医院普通外科,江苏221002 [2]江苏省肿瘤生物治疗重点实验室

出　　处：《中华实验外科杂志》2013年第8期1749-1750,共2页Chinese Journal of Experimental Surgery

摘　　要：目的探讨调节性T淋巴细胞（Tregs）在结肠癌组织中不同部位的浸润及临床意义。方法采用免疫组织化学技术检测90例原发性结肠腺癌组织芯片中局部浸润Tregs在癌巢、癌间质及癌旁正常黏膜的分布及其与总生存率（Os）的关系。结果癌组织中浸润Tregs多于癌旁正常黏膜浸润Tregs（P〈0．01）；癌巢浸润Tregs少于癌间质浸润Tregs（P〈0．01）；癌组织浸润Tregs与0s呈正相关（P〈0．05），癌巢浸润Tregs与OS呈负相关（P〈0．05）。结论结肠癌局部浸润Tregs与预后密切相关。Objective To investigate the correlation between tumor-infiltrating regulatory T cells （Tregs） in different parts of colon carcinoma and the clinical prognostic values. Methods The distribu- tion of tumor-infiltrating Tregs in the cancer nest, cancer stroma and normal mucosa of 90 cases of colon carcinoma was detected by using tissue microarray and immunohistochemistry staining technique, and its correlation with the overall survival （OS） was analyzed. Results The average number of intratumoral Tregs was significantly greater than that in corresponding normal mucosa tissues （P 〈 0.01 ） ; the average number of Tregs in cancer nest was significantly less than that in corresponding cancer stroma tissues （P 〈 0. 01 ） ; the number of intratumoral Tregs was positively correlated with OS （ P 〈 0. 05 ） ; the number of Tregs in cancer nest was negatively correlated with OS （P 〈 0. 05）. Conclusion The number of tumor-in- filtrating Tregs is closely associated with the prognosis of colon carcinoma. The Tregs in cancer nest are promising independent predictor for OS in colon carcinoma.

关 键 词：结肠癌 调节性T淋巴细胞 

分 类 号：R735.3[医药卫生—肿瘤]