心脏停跳复苏犬大脑组织内皮素-1含量和Na^+-K^+ATP酶活性的变化  

Changes of endothelin-1 content and Na^+-K^+ ATPase activity in brain tissue in resuscitated dogs after cardiac arrest

作　　者：金修才[1] 杨兴易[1] 赵良[1] 许永华[1] 景炳文[1] 王永进 

机构地区：[1]上海第二军医大学附属长征医院急救科,200003

出　　处：《中国急救医学》2000年第8期451-452,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　研究犬心脏停跳及复苏后脑组织内皮素 - 1(Endothelin ,ET - 1)含量、Na+ -K+ ATP酶活性的变化 ,探讨ET - 1在复苏后脑损伤中的可能作用机制。方法　采用犬室颤心跳呼吸骤停模型 ,进行标准心肺复苏 ,分别观察室颤前、心脏停跳 10min及复苏后 30min、2h和 4h的脑组织ET - 1含量和Na+ -K+ ATP酶活性变化及两者之间的关系。结果　心脏停跳及复苏后脑组织ET - 1含量明显升高 ,Na+ -K+ ATP酶活性降低 ,两者呈显著负相关。结论　心脏停跳及复苏后脑组织ET - 1含量升高引起脑组织损伤 ,其可能的作用机制之一是抑制了Na+ -K+ ATP酶的活性。Objective To investigate the possible mechanism of ET-1 in brain injury after cardiac arrest(CA)and postresuscitation.Methods The dogs with CA model of ventricular fibrillation were used to be resuscitated with standerd cardiopulmonary resuscitation.We observed the changes of ET-1 content and Na +-K + ATPase activity in brain tissue before ventricular fibrillation,after ten minutes of CA and postresuscitation 30 min,2 h,4 h respectively.Results ET-1 content was increased signifcantly and Na +-K + ATPase activity was decreased after ten minutes of CA and postresuscitation.There was a negative correlation between them.Conclusion ET-1 played a crucial role in brain tissue injury postresuscitation,one of the possible mechanism was associated with inhibition of Na +-K + ATPase activity. [

关 键 词：心脏停跳 NA^+-K^+ATP酶 内波素1 心脏复苏 

分 类 号：R363[医药卫生—病理学]