去泛素化酶与肿瘤发生及发展关系的研究进展  

Advances in the study of deubiquitinating enzymes in cancer research

作　　者：戴陈新[1] 袁健[2] 郑亚新[1] 

机构地区：[1]同济大学附属东方医院肝脏病科,上海200120 [2]同济大学附属东方医院转化医学平台,上海200120

出　　处：《中国癌症杂志》2013年第7期547-550,共4页China Oncology

基　　金：国家自然科学基金面上项目(No:31270806);国家自然科学基金青年基金(No:81102011)

摘　　要：去泛素化酶具有逆转泛素化的作用,其大多数研究还保留在分子生物学领域,在转化医学研究中尚未引起充分的重视。目前研究发现,去泛素化酶的目的蛋白通过各种途径影响肿瘤的发生、发展,如细胞凋亡和自噬、炎性反应和肿瘤的关系、肿瘤缺氧、肿瘤信号通路、细胞周期的调节和DNA损伤等。现就去泛素化酶与肿瘤发生、发展的关系及研究进展作一综述。Deubiquitinating enzymes, reversing protein ubiquitination, most of the researches focused on the field of molecular biology. However, it have not yet attracted enough attention in translational medicine research. In fact, target proteins of deubiquitinating enzymes affect the tumor progression through various ways, for example, cell apoptosis and autophagy, the link between inflammation and cancer, tumor hypoxia, signal transduction, cell cycle regulation and DNA damage. This paper reviewed the research progress on the relations between deubiquitinating enzymes and the correlated factors of tumor.

关 键 词：去泛素化 肿瘤 凋亡 信号传导 细胞周期 

分 类 号：R73-37[医药卫生—肿瘤]