乙醛脱氢酶1A1表达与乳腺癌淋巴结转移及预后关系研究  

Relationship of expression of ALDH1A1 in breast cancer with lymph node metastasis and prognosis

作　　者：彭智猷[1] 朱晨芳[1] 戚晓亮[1] 杨雪[1] 顾岩[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院普外科,上海200011

出　　处：《外科理论与实践》2013年第4期340-345,共6页Journal of Surgery Concepts & Practice

基　　金：国家自然科学基金(30872521);上海市卫生局青年科研项目(2009Y043)

摘　　要：目的:研究乙醛脱氢酶1(aldehyde dehydrogenase,ALDH1)亚型ALDH1A1在乳腺癌组织中的表达及其与乳腺癌淋巴结转移和临床预后的关系。方法:采用免疫组化方法检测72例原发性乳腺癌组织中ALDH1A1的表达,分析其表达与乳腺癌病人淋巴结转移、肿瘤分化、TNM分期及病人总生存期等临床因素间的关系。结果:72例乳腺癌病人中,淋巴结转移组(n=37)ALDH1A1阳性表达21例,占56.8%;非淋巴结转移组(n=35)ALDH1A1阳性表达8例,占22.9%,两组具有统计学差异(P<0.01)。ALDH1A1在伴淋巴结转移乳腺癌病人的表达显著高于不伴淋巴结转移者(P<0.01);但与病人的年龄、病理类型、肿瘤分级、TNM分期、分化程度和受体状态不相关(P>0.05)。Kaplan-Meier生存分析表明,ALDH1A1高表达组病人的总生存期、无病生存期、5年生存率和5年无病生存率均显著低于ALDH1A1低表达组,两组具有统计学差异(P<0.05)。单因素及多因素统计分析显示,ALDH1A1表达、淋巴结转移和TNM分期是与乳腺癌预后相关的重要独立因素,ALDH1A1高表达组病人预后显著差于ALDH1A1低表达组(P<0.05)。结论:乳腺癌ALDH1A1表达与淋巴结转移及预后显著相关,可作为预测乳腺癌淋巴结转移以及判断病人临床预后的重要指标。Objective To analyze the relationship between the expression of ALDH1A1 in breast cancer and the clinical factors. Methods The expression of ALDH1A1 was detected in 72 cases with breast cancer by immunohistochemical method. The relationship between ALDH1A1 expression and clinical characteristics including lymph node metastasis, tumor differentiation, TNM staging and overall survival time was analyzed. Results ALDH1A1 expressed in 21/37 （56.8%） cases of breast cancer with lymph node metastasis and only in 8/35 （22.9%） cases without. ALDH1A1 expression highly correlated with lymph node metastasis （P〈0.01）, but no significant relationship existed between ALDH1A1 expression and other clinical factors such as TNM stage, tumor differentiation and receptor status （P〉0.05）. Kaplan-Meier analysis showed higher value of overall survival time, disease free survival time, 5-year survival rate and 5- year disease free survival rate in the group with lower ALDH1A1 expression （P〈0.05）. Both univariate and multivariate analyses showed that ALDH1A1 expression, lymph node metastasis and TNM stage were independent prognostic factors of the patients with breast cancer （P〈0.05）. The higher expression of ALDH1A1 indicates a poorer prognosis. Conclusions ALDH1A1 might be a potential biomarker for lymph node metastasis and poorer clinical outcome in breast cancer.

关 键 词：乳腺癌 乙醛脱氢酶1A1 淋巴结转移 预后 

分 类 号：R737.9[医药卫生—肿瘤]