视网膜色素变性的多焦视网膜电图  

The multifocal electroretinogram in retinitis pigmentosa

作　　者：吴德正[1] 江福钿[1] 梁炯基[1] 罗苔青[1] 马娟妹[1] 高汝龙[1] 黄时洲[1] 吴乐正[1] 

机构地区：[1]广州中山医科大学中山眼科中心,510060

出　　处：《眼科研究》2000年第4期346-349,共4页Chinese Ophthalmic Research

摘　　要：目的研究视网膜色素变性（ＲＰ）的多焦视网膜电图（ＥＲＧ）特性和评价多焦ＥＲＧ应用价值。方法检测了 １２例（２４眼）ＲＰ患者的多焦 ＥＲＧ，测试野为２６．６°×２２．１°，记录 １０３个部位的反应，同时检测全视野 ＥＲＧ。结果ＲＰ眼在各个环的ａ波和ｂ波潜伏期、ｂ波振幅密度和振幅之和均较正常值有显著延长和降低（Ｐ＜０．０５或Ｐ＜０．０１）。５０％患眼在第１环可记录到潜伏期正常、振幅密度和总和均降低的ｂ波，而７５％患眼的全视野ＥＲＧ呈平坦反应。结论 多焦ＥＲＧ能更有效地评价ＲＰ的黄斑区功能。Objective To investigate the characteristics of the multifocal electroretinogram (ERG) and to evaluate the application values of the multifocal ERG in retinitis pigmentosa (RP). Methods Multifocal ERGs were obtained using VERIS 4.0 visual evoked response imaging system for 12 patients (22 eyes) with RP and 36 normal subjects (42 eyes). The stimulative visual angles subtended ±26.6° horizontally and ±22.1° vertically. Burian-Allen contact lens electrode was used to record the responses from 103 retinal locations in 8 min (16 segments). The full field ERGs were obtained in the same patients. Results The latencies of a wave and b wave delayed significantly, and the amplitude densities and the amplitude summary of b wave decreased markedly at all rings in RP group compared with normal group (P<0. 05 or P<0.01 ). Fifty percent affected eyes at ring 1 and 33. 3% affected eyes at ring 2 showed normal latencies and reduced amplitude densities and amplitude summary of b wave of multifocal ERG. 92% affected eyes showed delayed latency and reduced amplitude densities and amplitude summary of b wave at ring 5 and ring 6 of MERG. Only 25% affected eyes recorded the markedly reduced amplitude and delayed latency of full field ERG,while 75% affected eyes showed flat response of full field ERG. conclusion Multifocal ERG can provide more information and evaluate the macular function more effectively than full field ERG for RP.

关 键 词：视网膜色素变性 多焦视网膜电图 视觉电生理 

分 类 号：R774[医药卫生—眼科]