CRABP-Ⅱ、FABP-5在颅咽管瘤中的表达  

Preliminary Study on Expression of CRABP-Ⅱand FABP-5 in Craniopharyngioma

作　　者：白刚[1,2] 罗林[1,2] 王行桥 倪炜[1,2] 左频[1,2] 袁红平[1,2] 

机构地区：[1]昆明医科大学第三附属医院 [2]云南省肿瘤医院神经外科,云南昆明650118 [3]山东省威海卫人民医院神经外科,山东威海264200

出　　处：《昆明医科大学学报》2013年第6期75-78,共4页Journal of Kunming Medical University

基　　金：云南省科技厅专项研究基金资助项目(2008CD038)

摘　　要：目的检测颅咽管瘤中CRABP-Ⅱ、FABP-5的表达,分析其与颅咽管瘤关系,探讨维甲酸靶向治疗颅咽管瘤的分子机制.方法采用荧光免疫组织化学技术(Fluorescent Immunostaining)分别检测39例AE、10例SP两种亚型颅咽管瘤及20例正常脑组织中CRABP-Ⅱ、FABP-5蛋白表达情况,分析2种类型颅咽管瘤细胞及正常脑组织细胞中其表达有无差异.结果 (1)49例颅咽管瘤与20例正常脑组织中CRABP-Ⅱ,FABP-5的表达差异无统计学意义(P>0.05);(2)在颅咽管瘤亚型中CRABP-Ⅱ及FABP-5表达差异无统计学意义(P>0.05).结论 CRABP-Ⅱ、FABP-5不能作为RA作用颅咽管瘤细胞的靶点,CRABP-Ⅱ/FABP-5稳态在本实验中不存在.Objective To detect the expression of CRABP- ]I and FABP-5 in craniopharyngioma cells, analyze the correlation between the expression and craniopharyngioma, and investigate the molecular mechanism of retinoic acid （RA） targeted therapy for craniopharyngioma. Methods The expression of CRABP-// and FABP-5 in 49 cases of craniopharyngioma （39 cases of AE and 10 cases of SP） was detected by fluorescence immunohistochemistry accompanied with 8 cases of normal brain tissues. The difference of expression between the craniopharyngioma cells and the normal brain tissues was analyzed. Results The difference of CRABP- II or FABP-5 positive rate expression between 49 cases of craniopahryngioma and 20 cases of normal brain tissue had no statistical significance （P 〉 0.05） . Also, there was no statistical significance of CRABP- Ⅱ and FABP-5 expression between cases of two subtypes craniopahryngioma （P 〉 0.05） . Conclusion CRABP- Ⅱ and FABP-5 could not be used as the target of RA role of craniopharyngioma cells, and the steady-state CRABP- Ⅱ/FABP-5 did not exist in this experiment.

关 键 词：FABP-5 CRABP-Ⅱ 颅咽管瘤 

分 类 号：R739.41[医药卫生—肿瘤]