力增强影响大鼠牙周组织前列腺素(PGE_2)表达变化的研究  

Effect of increased occlusal force on the expression of PGE_2 in the rat periodontium

作　　者：袁林[1] 周伟东[2] 赵云凤[1] 

机构地区：[1]华西医科大学口腔医学院,成都610041 [2]第一军医大学珠江医院

出　　处：《临床口腔医学杂志》2000年第3期133-134,共2页Journal of Clinical Stomatology

摘　　要：目的　检测力在正常及增强状态下 ,大鼠牙周细胞 PGE2 的动态表达 ,初探 PGE2 在牙周组织改建中的分子机理。方法　采用 HE染色和免疫组化的方法 ,观察牙周形态变化以及牙周组织中 PGE2 蛋白表达。结果　力增强引起牙周膜增宽、牙槽骨形成。牙周细胞中 PGE2 表达较正常力时明显增强。结论　力增强 ,促使牙周组织产生 PGE2 明显增多 ,诱发了破骨功能 ;同时 ,还激活了成骨功能。本实验从分子水平探讨了牙周组织改建的机理。WT5”BZ]Objective To study the expression of PGE 2 in the rat periodontal cells under normal and increased occlusal force, in order to explain the molecular mechanism of periodontium remodeling. Methods HE staining and immunohistochemistry techniques were applied to study the change in the histologic morphology and the expression of PGE 2 protein. Results Under the increased occlusal force, periodontal ligament width was enlarged and alveolar bone was formed; the expression level of PGE 2 increased apparently in periodontal cells. Conclusion Increased occlusal force induce the expression of PGE 2 increased apparently in periodontium. It approached initially the molecular mechanism of periodontium remodeling, suggested that the histologic morphology is closely related to the mechanical condition. [WT5”HZ]

关 键 词：HE力 前列腺素E2 牙周组织改建 免疫组化 

分 类 号：R781.402[医药卫生—口腔医学]