结直肠癌的DNA甲基化研究进展  

Research progress on the DNA methylation of colorectal cancer

作　　者：李晓阳[1,2] 颜才华[1,2] 马一杰[1,2] 陈小兵[1,2] 罗素霞[1,2] 

机构地区：[1]郑州大学附属肿瘤医院 [2]河南省肿瘤医院内科,河南郑州450008

出　　处：《中国医药导报》2013年第23期28-30,共3页China Medical Herald

基　　金：河南省医药卫生重大攻关项目及卫生部科研基金资助项目(编号WKJ2011010012)

摘　　要：结直肠癌的发生是肠上皮细胞上一系列的遗传学和表观遗传学改变的结果。众多研究表明,几乎所有的结直肠癌中都存在基因异常甲基化,尤其是启动子区域基因的异常甲基化在结直肠癌的发生发展中扮演着重要角色。对甲基化基因的研究发现,结直肠癌中存在一个独特的分子群,即CpG岛甲基化表现型,而且这类肿瘤存在高甲基化聚集现象。近年结直肠癌表观遗传学研究进展迅速,在结直肠癌发生发展、早期诊断、治疗及预后评价中具有重要的指导意义,有望成为一种重要的生物学标志。本文就DNA甲基化在结直肠癌表观遗传学中的研究进展做一综述。The occurrence of colorectal cancer results from a sequence of genetics and epigenetics change of the in testinal epithelial cells.Many studies show that,virtually all colorectal cancers have aberrantly methylated genes,es pecially aberrantly methylated genes of the promoter region play a functional role in colorectal cancer.The research re lated to methylated gene has revealed a unique molecular subgroup called CpG Island Methylator Phenotype,these tu mors have a particularly high frequency of methylated genes.In recent years,rapid progresses in epigenetics of col orectal cancer make a great significance for initiation and progression,early diagnosis,therapy,prognostic evaluation of colorectal cancer and is a kind of important biomarkers.The review focuses on the research progress of DNA methyla tion in epigenetics of colorectal cancer.

关 键 词：结直肠癌 DNA甲基化 表观遗传学 生物学标志 

分 类 号：R735.35[医药卫生—肿瘤]