胃癌及癌前病变组织中雌激素受体和P21^(ras)的表达及意义  

Expressions and significance of estrogen receptor and P21^(ras) in gastric carcinoma and precancerous lesion tissues

作　　者：吴小翎[1] 张小雨[1] 

机构地区：[1]重庆医科大学第二临床学院消化内科,400010

出　　处：《重庆医科大学学报》2000年第3期239-241,共3页Journal of Chongqing Medical University

摘　　要：目的 探讨雌激素受体（ＥＲ）和ｒａｓ原癌基因蛋白─Ｐ２１ｒａＳ的表达在胃癌发生、发展中的作用及与胃癌生物学行为的关系。方法 采用免疫组化ＳＰ法。结果 ＥＲ在慢性浅表性胃炎（２０例）、异型增生（２１例）中均为阴性，胃癌（４０例）的表达阳性率为４０％，三组比较有显著件差异（Ｉ＜０．０５）。ｐ２１ｒａｓ在慢性浅表性胃炎、异型增生、胃癌的表达阳性率分别为１０％、２３．８％、４７．５％，三组比较差异有显著性（Ｉ＜０．０５）。ＥＲ和Ｐ２１ｒａｓ的阳性表达在胃癌进展期显著高于早期（Ｉ＜０．０５）；在有淋巴结转移组亦显著高于无转移组（Ｉ＜０．０５）。结论 ＥＲ、Ｐ２１ｒａｓ参与了胃癌的发生、发展，Ｐ２１ｒａｓ可作为癌前病变的随访标志物，ＥＲ在胃癌具有肿瘤特异性，Ｐ２１ｒａｓ和ＥＲ阳性的胃癌可能具有更强的浸润与转移能力。Objective To study the relationship and significance between expression of estrogen receptor (ER) or p21ras and gastric cancer or precancerous lesion. Methods Expressions of ER and P21ras were examined by SP immunohistochemistry. Results Expression of ER was negative in 20 chronic superficial gastritis and 21 dysplasia, and the positive rate in gastric cancer was 40%. Positive P21ras expression of gastric cancer was observed in 47.5% and it was significantly higher than chronic superficial gastritis (10%) and dysplasia (23.8%) (P<0.05). The positive rates of ER and P21ras in advanced gastric carcinomas and the group with metastasis were significanly higher than those in early gastric carcinomas and the group without metastasis (P<0.05). Conclusion ER and P21 ras may play an important role in the process of carcinogenesis of gastric mucosa and be used as useful markers for the assessment of biological behavior of gastric carcinoma.

关 键 词：雌激素受体 P21^RAS 胃癌 癌前病变 免疫组化 

分 类 号：R735.202[医药卫生—肿瘤]